Carboxypeptidase A6

Definition:

May be involved in the proteolytic inactivation of enkephalins and neurotensin in some brain areas. May convert inactive angiotensin I into the biologically active angiotensin II. Releases a C-terminal amino acid, with preference for large hydrophobic C-terminal amino acids and shows only very weak activity toward small amino acids and histidine.

References:

[1]. Peter J Lyons, et al. Substrate specificity of human carboxypeptidase A6. J Biol Chem. 2010 Dec 3;285(49):38234-42. [Content Brief]

[2]. Peter J Lyons, et al. Characterization of carboxypeptidase A6, an extracellular matrix peptidase. J Biol Chem. 2008 Mar 14;283(11):7054-63. [Content Brief]

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