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Helicase POLQ-like

Definition:

Single-stranded 3'-5' DNA helicase that plays a key role in homology-driven double-strand break (DSB) repair. Involved in different DSB repair mechanisms that are guided by annealing of extensive stretches of complementary bases at break ends, such as microhomology-mediated end-joining (MMEJ), single-strand annealing (SSA) or synthesis-dependent strand annealing (SDSA). Possesses both DNA unwinding and annealing activities. Forms a complex with RAD51, stimulating HELQ DNA helicase activity and ability to unwing DNA. Efficiently unwinds substrates containing 3' overhangs or a D-loop. In contrast, interaction with the replication protein A (RPA/RP-A) complex inhibits DNA unwinding by HELQ but strongly stimulates DNA strand annealing. Triggers displacement of RPA from single-stranded DNA to facilitate annealing of complementary sequences.

References:

[1]. Roopesh Anand, et al. HELQ is a dual-function DSB repair enzyme modulated by RPA and RAD51. Nature. 2022 Jan;601(7892):268-273. [Content Brief]

[2]. Federica Marini, et al. A human DNA helicase homologous to the DNA cross-link sensitivity protein Mus308. J Biol Chem. 2002 Mar 8;277(10):8716-23. [Content Brief]

[3]. George-Lucian Moldovan, et al. DNA polymerase POLN participates in cross-link repair and homologous recombination. Mol Cell Biol. 2010 Feb;30(4):1088-96. [Content Brief]

[4]. Kei-ichi Takata, et al. Human DNA helicase HELQ participates in DNA interstrand crosslink tolerance with ATR and RAD51 paralogs. Nat Commun. 2013;4:2338. [Content Brief]

[5]. Spencer W Luebben, et al. Helq acts in parallel to Fancc to suppress replication-associated genome instability. Nucleic Acids Res. 2013 Dec;41(22):10283-97. [Content Brief]

[6]. Agnieszka A Tafel, et al. Human HEL308 localizes to damaged replication forks and unwinds lagging strand structures. J Biol Chem. 2011 May 6;286(18):15832-40. [Content Brief]

[7]. Tabitha Jenkins, et al. The HelQ human DNA repair helicase utilizes a PWI-like domain for DNA loading through interaction with RPA, triggering DNA unwinding by the HelQ helicase core. NAR Cancer. 2021 Jan 12;3(1):zcaa043. [Content Brief]

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