Small vasohibin-binding protein

Definition:

Enhances the tyrosine carboxypeptidase activity of VASH1 and VASH2, thereby promoting the removal of the C-terminal tyrosine residue of alpha-tubulin. This activity is critical for spindle function and accurate chromosome segregation during mitosis since microtuble detyronisation regulates mitotic spindle length and postioning. Also required to enhance the solubility and secretion of VASH1 and VASH2. Plays a role in axon and excitatory synapse formation.

References:

[1]. Joppe Nieuwenhuis, et al. Vasohibins encode tubulin detyrosinating activity. Science. 2017 Dec 15;358(6369):1453-1456. [Content Brief]

[2]. Faxiang Li, et al. Structural basis of tubulin detyrosination by vasohibins. Nat Struct Mol Biol. 2019 Jul;26(7):583-591. [Content Brief]

[3]. Chen Zhou, et al. Structural basis of tubulin detyrosination by VASH2/SVBP heterodimer. Nat Commun. 2019 Jul 19;10(1):3212. [Content Brief]

[4]. Na Wang, et al. Structural basis of tubulin detyrosination by the vasohibin-SVBP enzyme complex. Nat Struct Mol Biol. 2019 Jul;26(7):571-582. [Content Brief]

[5]. Athanassios Adamopoulos, et al. Crystal structure of the tubulin tyrosine carboxypeptidase complex VASH1-SVBP. Nat Struct Mol Biol. 2019 Jul;26(7):567-570. [Content Brief]

[6]. Shanhui Liao, et al. Molecular basis of vasohibins-mediated detyrosination and its impact on spindle function and mitosis. Cell Res. 2019 Jul;29(7):533-547. [Content Brief]

[7]. Yasuhiro Suzuki, et al. Isolation of a small vasohibin-binding protein (SVBP) and its role in vasohibin secretion. J Cell Sci. 2010 Sep 15;123(Pt 18):3094-101. [Content Brief]

[8]. Zafar Iqbal, et al. Loss of function of SVBP leads to autosomal recessive intellectual disability, microcephaly, ataxia, and hypotonia. Genet Med. 2019 Aug;21(8):1790-1796. [Content Brief]

[9]. Tetsuya Kadonosono, et al. Domain architecture of vasohibins required for their chaperone-dependent unconventional extracellular release. Protein Sci. 2017 Mar;26(3):452-463. [Content Brief]

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