TNF receptor-associated factor 6

[1]. Z Cao, et al. TRAF6 is a signal transducer for interleukin-1. Nature. 1996 Oct 3;383(6599):443-6. [Content Brief]

[2]. Caini Liu, et al. Act1, a U-box E3 ubiquitin ligase for IL-17 signaling. Sci Signal. 2009 Oct 13;2(92):ra63. [Content Brief]

[3]. Hong Ye, et al. Distinct molecular mechanism for initiating TRAF6 signalling. Nature. 2002 Jul 25;418(6896):443-7. [Content Brief]

[4]. Wei-Lei Yang, et al. The E3 ligase TRAF6 regulates Akt ubiquitination and activation. Science. 2009 Aug 28;325(5944):1134-8. [Content Brief]

[5]. Qian Yin, et al. E2 interaction and dimerization in the crystal structure of TRAF6. Nat Struct Mol Biol. 2009 Jun;16(6):658-66. [Content Brief]

[6]. Zong-Ping Xia, et al. Direct activation of protein kinases by unanchored polyubiquitin chains. Nature. 2009 Sep 3;461(7260):114-9. [Content Brief]

[7]. Ji-Ji Xie, et al. TNFR-associated factor 6 regulates TCR signaling via interaction with and modification of LAT adapter. J Immunol. 2013 Apr 15;190(8):4027-36. [Content Brief]

[8]. Yaya Wang, et al. Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling. Nat Immunol. 2006 Feb;7(2):139-47. [Content Brief]

[9]. Noula Shembade, et al. Essential role for TAX1BP1 in the termination of TNF-alpha-, IL-1- and LPS-mediated NF-kappaB and JNK signaling. EMBO J. 2007 Sep 5;26(17):3910-22. [Content Brief]

[10]. Alessandro Sorrentino, et al. The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner. Nat Cell Biol. 2008 Oct;10(10):1199-207. [Content Brief]

[11]. L Deng, et al. Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell. 2000 Oct 13;103(2):351-61. [Content Brief]

[12]. Dietrich B Conze, et al. Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB activation. Mol Cell Biol. 2008 May;28(10):3538-47. [Content Brief]

[13]. Yin Yang, et al. The Us3 Protein of Herpes Simplex Virus 1 Inhibits T Cell Signaling by Confining Linker for Activation of T Cells (LAT) Activation via TRAF6 Protein. J Biol Chem. 2015 Jun 19;290(25):15670-15678. [Content Brief]

[14]. Betty Lamothe, et al. Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation. J Biol Chem. 2007 Feb 9;282(6):4102-12. [Content Brief]

[15]. Lan V Pham, et al. Nuclear tumor necrosis factor receptor-associated factor 6 in lymphoid cells negatively regulates c-Myb-mediated transactivation through small ubiquitin-related modifier-1 modification. J Biol Chem. 2008 Feb 22;283(8):5081-9. [Content Brief]