Zinc finger protein Eos

Definition:

DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Essential for the inhibitory function of regulatory T-cells (Treg). Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1 (By similarity).

References:

[1]. Joseph Koipally, et al. A molecular dissection of the repression circuitry of Ikaros. J Biol Chem. 2002 Aug 2;277(31):27697-705. [Content Brief]

[2]. José Perdomo, et al. The Ikaros family protein Eos associates with C-terminal-binding protein corepressors. Eur J Biochem. 2002 Dec;269(23):5885-92. [Content Brief]

[3]. J Perdomo, et al. Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities. J Biol Chem. 2000 Dec 8;275(49):38347-54. [Content Brief]

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