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Cat. No.: HY-P1336A

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Deltorphin I TFA

(Synonyms: Deltorphin 1 TFA; Deltorphin C TFA; [D-Ala2] Deltorphin I TFA)

Deltorphin I TFA (Deltorphin 1 TFA; Deltorphin C TFA; [D-Ala2] Deltorphin I TFA) is a high-affinity, selective δ-opioid receptor agonist that targets the δ1 and δ2 opioid receptor subtypes. Deltorphin I TFA produces analgesic effects in the rat spinal cord. Deltorphin I TFA increases the pain threshold in rats. Deltorphin I TFA can be used in studies related to nociception (acute pain).

For research use only. We do not sell to patients.

CAS No.: 2952824-50-7
Formula: C₃₉H₅₃F₃N₈O₁₂
Molecular Weight:882.88

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Custom Peptide Synthesis

Deltorphin I TFA Chemical Structure

CAS No.: 2952824-50-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

δ Opioid Receptor/DOR

All Opioid Receptor Isoforms :

In Vivo

Deltorphin I (0.15-15 μg; intrathecal injection; single administration) TFA exerts dose-dependent analgesic effects in acute nociception tests in rats by activating δ1 and δ2 opioid receptors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Wistar rats (male, 260-350 g, intrathecal lumbar enlargement catheter implantation)^[1]
Dosage:

0.15 μg; 1.5 μg; 15 μg
Administration:

i.th.; single injection
Result:

Significantly increased tail-flick latency in a dose-dependent manner, with effects starting at 15 minutes post-injection and lasting for 120 minutes.
Reached maximum effect at 15 minutes for all doses, with duration of effect increasing with higher doses.
Significantly increased paw pressure threshold at 1.5 μg and 15 μg doses starting at 15 minutes post-injection; showed no effect at 0.15 μg dose.
Had its antinociceptive effect significantly antagonized by coadministration of 30 μg NTI, 3 μg NTB, or 1 μg BNTX in both tail-flick and paw pressure tests.
Had its effect completely blocked by NTI in the paw pressure test.

Chemical Information

CAS No. 2952824-50-7
Molecular Weight 882.88
Formula C₃₉H₅₃F₃N₈O₁₂
Synonyms

Deltorphin 1 TFA; Deltorphin C TFA; [D-Ala2] Deltorphin I TFA
Sequence

Tyr-Ala-Phe-Asp-Val-Val-Gly
Sequence Shortening

YAFDVVG
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Labuz D, et al. Antinociceptive effects of isoleucine derivatives of deltorphin I and deltorphin II in rat spinal cord: a search for selectivity of delta receptor subtypes. Neuropeptides. 1998;32(6):511-517. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

100 mg

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