Gabra4 - gamma-aminobutyric acid type A receptor subunit alpha 4 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 140675

Summary

Enables transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in several processes, including GABAergic synaptic transmission; chloride transmembrane transport; and gamma-aminobutyric acid signaling pathway. Predicted to act upstream of or within central nervous system development. Is active in GABA-ergic synapse. Is integral component of postsynaptic specialization membrane. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human GABRA4 (gamma-aminobutyric acid type A receptor subunit alpha4). [provided by Alliance of Genome Resources, Apr 2022]

Gabra4 Products (1)

mRNA Protein Name
NM_080587.3 NP_542154.3 gamma-aminobutyric acid receptor subunit alpha-4 precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential EXP
EXP: Inferred from Experiment
16467523 RGD
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IDA
IDA: Inferred from direct assay
16467523 RGD
Cellular Component GO Annotation Evidence References Source
is active in GABA-ergic synapse EXP
EXP: Inferred from Experiment
16467523 RGD
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
16467523 RGD
is active in postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
16467523 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

gamma-aminobutyric acid receptor subunit alpha-4

  • GABA(A) receptor subunit alpha-4

  • GABA-A receptor alpha-4 subunit

  • gamma-aminobutyric acid (GABA) A receptor, alpha 4

  • gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 4

  • gamma-aminobutyric acid type A receptor alpha4 subunit

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05212 GABRA4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20552 Gabra4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27061 Gabra4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gabra4 NCBI NCBI:2557