ADAMTS14 - ADAM metallopeptidase with thrombospondin type 1 motif 14 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 140766

About ADAMTS14

Cytogenetic location: 10q22.1 Genomic coordinates (GRCh38): 10:70,672,506-70,762,441 (from NCBI)

This gene has 2 transcripts (splice variants), 199 orthologues and 25 paralogues. Biased expression in gall bladder (RPKM 3.7), placenta (RPKM 3.6) and 13 other tissues.

Summary

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme cleaves amino-terminal propeptides from type I procollagen, a necessary step in the formation of Collagen fibers. Mutations in this gene may be associated with osteoarthritis in human patients. [provided by RefSeq, May 2016]

ADAMTS14 Products (2)

mRNA Protein Name
NM_080722.4 NP_542453.2 A disintegrin and metalloproteinase with thrombospondin motifs 14 isoform 2 preproprotein
NM_139155.3 NP_631894.2 A disintegrin and metalloproteinase with thrombospondin motifs 14 isoform 1 precursor

ADAMTS14 Protein Structure

Pep_M12B_propep

Pep_M12B_propep: Reprolysin family propeptide (91 - 207)

Reprolysin

Reprolysin: Reprolysin (M12B) family zinc metalloprotease (261 - 460)

TSP_1

TSP_1: Thrombospondin type 1 domain (556 - 606)

ADAM_spacer1

ADAM_spacer1: ADAM-TS Spacer 1 (714 - 829)

TSP_1

TSP_1: Thrombospondin type 1 domain (855 - 906)

TSP_1

TSP_1: Thrombospondin type 1 domain (913 - 952)

TSP_1

TSP_1: Thrombospondin type 1 domain (975 - 1021)

  • 0
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  • 1223 a.a.
Protein Preferred Names Protein Names

A disintegrin and metalloproteinase with thrombospondin motifs 14

  • a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 14

Related Diseases

Diseases Alias
Tibialis Tendinitis
Patellar Tendinitis

  • Patellar Tendonitis
Osteoarthritis

  • Osteoarthrosis

  • Degenerative Joint Disease

  • Hypertrophic Arthritis

  • Arthropathy

  • Degenerative Polyarthritis

  • Degenerative Arthritis

  • Osteoarthrosis And Allied Disorder

  • Arthritis, Degenerative

  • Oa

  • Osteoarthritis Deformans

  • Osteoarthrosis Deformans

  • Kashin-Beck Disease
Radial Nerve Lesion

  • Lesion Of Radial Nerve

  • Radial Nerve Lesions

  • Radial Neuropathy

  • Radial Nerve Mononeuritis
Radial Neuropathy
Hennekam Syndrome

  • Hennekam Lymphangiectasia Lymphedema Syndrome

  • Hennekam Lymphangiectasia-Lymphedema Syndrome

  • Lymphedema-Lymphangiectasia-Intellectual Disability Syndrome

  • Lymphedem-Lymphangiectasia-Intellectual Disability Syndrome

  • Intestinal Lymphagiectasia Lymphedema Intellectual Deficit Syndrome

  • Lymphangiectasies And Lymphedema Hennekam Type

  • Generalized Lymphatic Dysplasia

  • Intestinal Lymphagiectasia-Lymphedema-Mental Retardation Syndrome
Ehlers-Danlos Syndrome, Classic Type, 1

  • Ehlers-Danlos Syndrome, Type I

  • EDSCL1

  • Ehlers-Danlos Syndrome Classic Type 1

  • Ehlers-Danlos Syndrome Type 1

  • Ehlers-Danlos Syndrome, Type I, Formerly

  • Eds1, Formerly

  • Ehlers-Danlos Syndrome, Severe Classic Type, Formerly

  • Eds I, Formerly

  • Ehlers-Danlos Syndrome, Gravis Type, Formerly

  • Ehlers-Danlos Syndrome, Type 1

  • Type I Ehlers-Danlos Syndrome

  • Eds1

  • Eds I

  • Ehlers-Danlos Syndrome, Gravis Type

  • Ehlers-Danlos Syndrome, Severe Classic Type

  • Ehlers-Danlos Syndrome 1

  • Ehlers-Danlos, Classic Syndrome, Type 1

  • Ehlers-Danlos Syndrome Type 2
Weill-Marchesani Syndrome

  • Gemss Syndrome

  • Spherophakia-Brachymorphia Syndrome

  • Marchesani-Weill Syndrome

  • Wms

  • Congenital Mesodermal Dystrophy

  • Mesodermal Dysmorphodystrophy, Congenital

  • Spherophakia Brachymorphia Syndrome

  • Mesodermal Dysmorphodystrophy Congenital

  • Wm Syndrome

  • Brachydactyly-Spherophakia Syndrome

  • Brachymorphy With Spherophakia Syndrome

  • Congenital Mesodermal Dysmorphodystrophy

  • Marchesani Syndrome

  • Weill-Marchesani Syndrome, Autosomal Recessive

  • Weill-Marchesani Syndrome, Autosomal Dominant
Ehlers-Danlos Syndrome

  • Eds

  • Cutis Hyperelastica

  • Elastic Skin

  • Ehlers-Danlos Syndromes

  • Ed Syndrome

  • Ehlers Danlos Syndrome

  • Ehlers Danlos Disease

  • Eds - [Ehlers-Danlos Syndrome]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00295 ADAMTS14 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20226 Adamts14 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26733 Adamts14 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ADAMTS14 VGNC VGNC:25618
Felis catus ADAMTS14 VGNC VGNC:59588
Canis familiaris ADAMTS14 VGNC VGNC:37593
Macaca mulatta ADAMTS14 VGNC VGNC:69407
Mus musculus ADAMTS14 MGD MGI:2179942
Rattus norvegicus ADAMTS14 RGD RGD:1308899
Others ADAMTS14 NCBI