Nnt - nicotinamide nucleotide transhydrogenase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 310378

Summary

Predicted to enable NAD binding activity; NAD(P)+ transhydrogenase activity; and NADP binding activity. Involved in several processes, including cell redox homeostasis; oxygen homeostasis; and positive regulation of hydrogen peroxide catabolic process. Located in mitochondrion. Biomarker of obesity. Human ortholog(s) of this gene implicated in familial glucocorticoid deficiency. Orthologous to human NNT (nicotinamide nucleotide transhydrogenase). [provided by Alliance of Genome Resources, Apr 2022]

Nnt Products (1)

mRNA Protein Name
NM_001013157.1 NP_001013175.1 NAD(P) transhydrogenase, mitochondrial

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in NADPH regeneration IMP
IMP: Inferred from mutant phenotype
22198343 RGD
involved in cell redox homeostasis IMP
IMP: Inferred from mutant phenotype
22198343 RGD
involved in cellular oxidant detoxification IMP
IMP: Inferred from mutant phenotype
22198343 RGD
involved in intracellular oxygen homeostasis IMP
IMP: Inferred from mutant phenotype
24722990 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
22198343 RGD
involved in negative regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
22198343 RGD
involved in positive regulation of hydrogen peroxide catabolic process IMP
IMP: Inferred from mutant phenotype
24722990 RGD
involved in positive regulation of mitochondrial membrane potential IMP
IMP: Inferred from mutant phenotype
24722990 RGD
involved in response to vitamin IEP
IEP: Inferred from expression pattern
25761734 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

NAD(P) transhydrogenase, mitochondrial

  • Nicotinamide nucleotide transhydrogenase (NAD(P)+ transhydrogenase)

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS26749 Nnt Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09396 NNT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20241 Nnt Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nnt NCBI NCBI:23530