ALDH8A1 - aldehyde dehydrogenase 8 family member A1 Gene

Also Known as ALDH12; DJ352A20.2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64577

About ALDH8A1

Cytogenetic location: 6q23.3 Genomic coordinates (GRCh38): 6:134,917,393-134,950,101 (from NCBI)

This gene has 6 transcripts (splice variants), 207 orthologues and 17 paralogues. Biased expression in liver (RPKM 60.7) and kidney (RPKM 37.6).

Summary

This gene encodes a member of the aldehyde dehydrogenase family of proteins. The encoded protein has been implicated in the synthesis of 9-cis-retinoic acid and in the breakdown of the amino acid tryptophan. This enzyme converts 9-cis-retinal into the retinoid X receptor ligand 9-cis-retinoic acid, and has approximately 40-fold higher activity with 9-cis-retinal than with all-trans-retinal. In addition, this enzyme has been shown to catalyze the conversion of 2-aminomuconic semialdehyde to 2-aminomuconate in the kynurenine pathway of tryptophan catabolism. [provided by RefSeq, Jul 2018]

ALDH8A1 Products (3)

mRNA Protein Name
NM_001193480.2 NP_001180409.1 2-aminomuconic semialdehyde dehydrogenase isoform 3
NM_022568.4 NP_072090.1 2-aminomuconic semialdehyde dehydrogenase isoform 1
NM_170771.3 NP_739577.1 2-aminomuconic semialdehyde dehydrogenase isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables retinal dehydrogenase activity IDA
IDA: Inferred from direct assay
11007799 GOA
Biological Process GO Annotation Evidence References Source
involved in retinal metabolic process IDA
IDA: Inferred from direct assay
11007799 GOA
involved in retinoic acid metabolic process IDA
IDA: Inferred from direct assay
11007799 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ALDH8A1 Protein Structure

Aldedh

Aldedh: Aldehyde dehydrogenase family (23 - 483)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 487 a.a.
Protein Preferred Names Protein Names

2-aminomuconic semialdehyde dehydrogenase

  • aldehyde dehydrogenase 12

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00581 ALDH8A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ALDH8A1 VGNC VGNC:59739
Bos taurus ALDH8A1 VGNC VGNC:25819
Canis familiaris ALDH8A1 VGNC VGNC:37790
Macaca mulatta ALDH8A1 VGNC VGNC:69611
Mus musculus ALDH8A1 MGD MGI:2653900
Rattus norvegicus ALDH8A1 RGD RGD:1590218
Others ALDH8A1 NCBI