LPGAT1 - lysophosphatidylglycerol acyltransferase 1 Gene

Also Known as NET8; FAM34A; LPLAT7; FAM34A1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9926

About LPGAT1

Cytogenetic location: 1q32.3 Genomic coordinates (GRCh38): 1:211,743,457-211,830,763 (from NCBI)

This gene has 4 transcripts (splice variants), 206 orthologues and 4 paralogues. Ubiquitous expression in small intestine (RPKM 15.0), thyroid (RPKM 14.6) and 25 other tissues.

Summary

This gene encodes a member of the lysophospholipid Acyltransferase family. The encoded protein catalyzes the reacylation of lysophosphatidylglycerol to phosphatidylglycerol, a membrane phospholipid that is an important precursor for the synthesis of cardiolipin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

LPGAT1 Products (6)

mRNA Protein Name
NM_001320808.2 NP_001307737.1 acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform 1
NM_001375841.1 NP_001362770.1 acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform 1
NM_001375842.1 NP_001362771.1 acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform 1
NM_001375844.1 NP_001362773.1 acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform 2
NM_001375845.1 NP_001362774.1 acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform 2
NM_014873.3 NP_055688.1 acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 2-acylglycerophosphocholine O-acyltransferase activity IDA
IDA: Inferred from direct assay
36049524 GOA
enables lysophospholipid acyltransferase activity IDA
IDA: Inferred from direct assay
36049524 GOA
enables lysophospholipid acyltransferase activity IMP
IMP: Inferred from mutant phenotype
15485873 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of fatty acid biosynthetic process IMP
IMP: Inferred from mutant phenotype
23749231 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
10942595 GOA
located in endoplasmic reticulum membrane IMP
IMP: Inferred from mutant phenotype
15485873 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LPGAT1 Protein Structure

Acyltransferase

Acyltransferase: Acyltransferase (89 - 200)

  • 0
  • 100
  • 200
  • 300
  • 370 a.a.
Protein Preferred Names Protein Names

acyl-CoA:lysophosphatidylglycerol acyltransferase 1

  • acyl-CoA:monoacylglycerol acyltransferase LPGAT1

Related Diseases

Diseases Alias
Progressive Familial Heart Block, Type Ii

  • PFHB2

  • Pfhbii

  • Progressive Familial Heart Block Type Ii

  • Progressive Familial Heart Block Type 2

  • Heart Block Progressive Familial Type 2
Cardiomyopathy, Dilated, 1d

  • Dilated Cardiomyopathy 1d

  • CMD1D

  • Left Ventricular Noncompaction 6, Included

  • Lvnc6, Included

  • Left Ventricular Noncompaction 6

  • Cardiomyopathy, Dilated 1d
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS21147 Lpgat1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07768 LPGAT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27664 Lpgat1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus LPGAT1 RGD RGD:1585897
Mus musculus LPGAT1 MGD MGI:2446186
Macaca mulatta LPGAT1 VGNC VGNC:74387
Bos taurus LPGAT1 VGNC VGNC:30965
Felis catus LPGAT1 VGNC VGNC:107894
Canis familiaris LPGAT1 VGNC VGNC:42750
Others LPGAT1 NCBI