(-)-Isodocarpin
Based on 1 Customer Validation
(-)-Isodocarpin (Isodocarpin), a diterpenoid, is a potent melanogenesis inhibitor with an IC50 of 0.19 μM in B16 4A5 cells. (-)-Isodocarpin inhibits the expression of tyrosinase, tyrosine-related protein (TRP)-1, and TRP-2 mRNA.
For research use only. We do not sell to patients.
- Purity: 99.78%
- CAS No.: 10391-08-9
- Formula: C20H26O5
- Molecular Weight:346.42
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
3.2 μM
Compound: 14
|
Cytotoxicity against human A549 cells after 48 hrs by MTS assay
Cytotoxicity against human A549 cells after 48 hrs by MTS assay
|
[PMID: 24219809] |
| HL-60 | IC50 |
2.8 μM
Compound: 14
|
Cytotoxicity against human HL60 cells after 48 hrs by MTS assay
Cytotoxicity against human HL60 cells after 48 hrs by MTS assay
|
[PMID: 24219809] |
| MCF7 | IC50 |
2.6 μM
Compound: 14
|
Cytotoxicity against human MCF7 cells after 48 hrs by MTS assay
Cytotoxicity against human MCF7 cells after 48 hrs by MTS assay
|
[PMID: 24219809] |
| RAW264.7 | IC50 |
2.2 μM
Compound: 14
|
Inhibition of LPS-stimulated NO production in mouse RAW264.7 cells after 18 hrs by Griess assay
Inhibition of LPS-stimulated NO production in mouse RAW264.7 cells after 18 hrs by Griess assay
|
[PMID: 24219809] |
| SMMC-7721 | IC50 |
3.5 μM
Compound: 14
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Cytotoxicity against human SMMC7721 cells after 48 hrs by MTS assay
Cytotoxicity against human SMMC7721 cells after 48 hrs by MTS assay
|
[PMID: 24219809] |
| SW480 | IC50 |
1 μM
Compound: 14
|
Cytotoxicity against human SW480 cells after 48 hrs by MTS assay
Cytotoxicity against human SW480 cells after 48 hrs by MTS assay
|
[PMID: 24219809] |
Chemical Information
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CAS No. 10391-08-9
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Appearance Solid
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Molecular Weight 346.42
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Formula C20H26O5
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Color White to off-white
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SMILES
O[C@H]1[C@@]2([H])[C@]3(CO1)[C@@]4([H])[C@@]5(C(O[C@@]3([H])CCC2(C)C)=O)C[C@@](C(C5=O)=C)([H])CC4
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Synonyms
Isodocarpin
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Purity & Documentation
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Data Sheet (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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