Ardisianone
Ardisianone is a component with an alkyl benzoquinone structure that can be isolated from Ardisia virens Kurz and Ardisia compressa tea extract. Ardisianone exhibits potent antileukemic activity, particularly against HL-60 cells, with IC50 values of 1.87 μM (24 h) and 1.67 μM (48 h). Ardisianone induces caspase-dependent apoptosis and triggers pyroptosis. Ardisianone can be used for the study of acute myeloid leukemia (AML).
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- CAS No.: 66398-68-3
- Formule: C24H38O5
- Masse moléculaire:406.56
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Stockage:
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Ardisianone (1-5 μM, 24-48 h) induces apoptosis and shows potent cytotoxic activity against HL-60 cells, with IC50 values of 1.87 μM (24 h) and 1.67 μM (48 h)[1].
Ardisianone (2-5 μM, 24 h) exerts pyroptosis-inducing activity in HL-60 cells[1].
Ardisianone (0.5-2 μM, 72 h) significantly increases CD11b expression and CD68 expression, and induces differentiation into monocyte-like and macrophage-like morphologies in HL-60 cells[1].
Ardisianone (2 μM) shows DNA damage-inducing activity in HL-60 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HL-60 cells
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Concentration:1, 2, 3, 4, 5 μM
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Incubation Time:3, 6, 9, 12, 15, 24 h
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Result:Induced apoptosis in HL-60 cells and concentration-dependent elevation of sub-G1 apoptotic population.
Induced profound degradation of DFF45/ICAD.
Upregulated death receptors (especially TNFR2).
Downregulated IAPs (cIAP1, cIAP2, survivin).
Promoted time-dependent activation of caspase-8/-3 and degradation of Bid.
Chemical Information
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CAS No. 66398-68-3
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Masse moléculaire 406.56
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Formule C24H38O5
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SMILES
CCCCCCCCCCCCC[C@@H](OC(C)=O)CC(C(C(OC)=C1)=O)=CC1=O
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ardisianone Related Classifications
HY-N12641 Related Classifications
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