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Cat. No.: HY-182399

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BC-DXI-495

BC-DXI-495 is a AIMP2-DX2 inhibitor. BC-DXI-495 disrupts the interaction of HSP70 and destabilizes DX2. BC-DXI-495 induces DX2 degradation via Siah1-mediated ubiquitination. BC-DXI-495 exerts tumor suppressive activity in cancer cells. BC-DXI-495 serves as a chemical probe to elucidate the mechanism of action of arylsulfonamide-based DX2 inhibitors. BC-DXI-495 can be used in lung cancer research.

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CAS No.: 2421117-94-2
Formule: C₂₈H₃₀N₄O₄S
Masse moléculaire:518.63

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Please store the product under the recommended conditions in the Certificate of Analysis.

BC-DXI-495 Chemical Structure

CAS No.: 2421117-94-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
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Activité biologique

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	EC₅₀	14.2 μM Compound: 2; BC-DXI-495	Antiproliferative activity against human A549 cells measured after 72 hrs by MTT assay Antiproliferative activity against human A549 cells measured after 72 hrs by MTT assay	[PMID: 32315177]

In Vitro

BC-DXI-495 (Compound 2) inhibits the level of NanoLuciferase-tagged DX2 by 67.10%^[1].
BC-DXI-495 inhibits the degradation of DX2 protein, with an IC₅₀ value of 4.20 μM^[1].
BC-DXI-495 (72 h) inhibits the viability of A549 lung cancer cells with an EC₅₀ of 14.2 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2421117-94-2
Masse moléculaire 518.63
Formule C₂₈H₃₀N₄O₄S
SMILES

O=S(N[C@H](C(NC1=CC=C(N2CCOCC2)C=C1)=O)CC3=CNC4=CC=CC=C34)(C5=CC=C(C=C5)C)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Sivaraman A, et al. Synthesis and Structure-Activity Relationships of Arylsulfonamides as AIMP2-DX2 Inhibitors for the Development of a Novel Anticancer Therapy. J Med Chem. 2020;63(10):5139-5158. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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