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Cat. No.: HY-182696

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CGS 24891

CGS 24891 is an orally active 5-lipoxygenase (5-LO) inhibitor, with an IC₅₀ value of 0.051 μM in guinea pigs and 0.11 μM in dogs. CGS 24891 inhibits the production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B₄ (LTB₄) from arachidonic acid. CGS 24891 weakly inhibits 12-lipoxygenase (12-LO) with an IC₅₀ of 0.41 μM. CGS 24891 is applicable to research on inflammation and allergic reactions.

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CAS No.: 134823-10-2
Formule: C₁₈H₁₇FN₂O₄
Masse moléculaire:344.34

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Please store the product under the recommended conditions in the Certificate of Analysis.

CGS 24891 Chemical Structure

CAS No.: 134823-10-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

IC₅₀ & Target^[1]

5-LO

0.051 (gui μM (IC₅₀)

5-LO

0.11 (dogs μM (IC₅₀)

12-LOX

0.41 μM (IC₅₀)

Voir tous les produits spécifiques à Isoform Lipoxygenase :

In Vitro

CGS 24891 potently inhibits 5-lipoxygenase activity in guinea pig polymorphonuclear leukocytes (PMNs) with an IC₅₀ value of 51 nM^[1].
CGS 24891 inhibits the activity of 5-lipoxygenase in canine whole blood, with an IC₅₀ of 0.11 μM^[1].
CGS 24891 inhibits 12-lipoxygenase activity in platelets with an IC₅₀ of 0.41 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CGS 24891 (1 mg/kg; p.o.) exerts a duration of action of 15 h in dogs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 134823-10-2
Masse moléculaire 344.34
Formule C₁₈H₁₇FN₂O₄
SMILES

O=C(N(CC1=CC2=C(OC1)C=CC(OC3=CC=C(C=C3)F)=C2)O)NC
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Satoh Y, et al. Substituted chromenes as potent, orally active 5-lipoxygenase inhibitors. J Med Chem. 1993;36(23):3580-3594. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références

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CGS 24891

Voir tous les produits spécifiques à Isoform Lipoxygenase

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

CGS 24891 Related Classifications

HY-182696 Related Classifications