Deltorphin I TFA
Deltorphin I TFA (Deltorphin 1 TFA; Deltorphin C TFA; [D-Ala2] Deltorphin I TFA) is a high-affinity, selective δ-opioid receptor agonist that targets the δ1 and δ2 opioid receptor subtypes. Deltorphin I TFA produces analgesic effects in the rat spinal cord. Deltorphin I TFA increases the pain threshold in rats. Deltorphin I TFA can be used in studies related to nociception (acute pain).
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- CAS No.: 2952824-50-7
- Formule: C39H53F3N8O12
- Masse moléculaire:882.88
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Activité biologique
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δ Opioid Receptor/DOR |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar rats (male, 260-350 g, intrathecal lumbar enlargement catheter implantation)[1]
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Dosage:0.15 μg; 1.5 μg; 15 μg
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Administration:i.th.; single injection
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Result:Significantly increased tail-flick latency in a dose-dependent manner, with effects starting at 15 minutes post-injection and lasting for 120 minutes.
Reached maximum effect at 15 minutes for all doses, with duration of effect increasing with higher doses.
Significantly increased paw pressure threshold at 1.5 μg and 15 μg doses starting at 15 minutes post-injection; showed no effect at 0.15 μg dose.
Had its antinociceptive effect significantly antagonized by coadministration of 30 μg NTI, 3 μg NTB, or 1 μg BNTX in both tail-flick and paw pressure tests.
Had its effect completely blocked by NTI in the paw pressure test.
Chemical Information
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CAS No. 2952824-50-7
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Masse moléculaire 882.88
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Formule C39H53F3N8O12
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Synonyms
Deltorphin 1 TFA; Deltorphin C TFA; [D-Ala2] Deltorphin I TFA
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Sequence
Tyr-Ala-Phe-Asp-Val-Val-Gly
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Sequence Shortening
YAFDVVG
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Deltorphin I TFA Related Classifications
HY-P1336A Related Classifications
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- Deltorphin I
- 2952824-50-7
- Deltorphin 1
- Deltorphin C
- [D-Ala2] Deltorphin I
- Deltorphin1
- Deltorphin-1
- Opioid Receptor
- nociceptive threshold
- rat spinal cord
- rat paw pressure test
- δ opioid receptor
- antinociceptive effects
- nociception
- acute pain
- δ2 opioid receptor
- rat tail-flick test
- δ1 opioid receptor
- Inhibitor
- inhibitor
- inhibit