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Cat. No.: HY-174913

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Factor B-IN-5

Factor B-IN-5 is an orally active complement factor B (CFB) inhibitor. Factor B-IN-5 alleviates kidney damage in diabetes nephropathy by inhibiting the over activation of complement system and improving mitochondrial function. Factor B-IN-5 can improve renal tubulointerstitial inflammation and fibrosis. Factor B-IN-5 can be used for research on diabetic nephropathy.

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CAS No.: 1644670-23-4
Formule: C₂₄H₂₈N₂O₃
Masse moléculaire:392.49

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Factor B-IN-5 Chemical Structure

CAS No.: 1644670-23-4

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Activité biologique
- Description
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

In Vivo

Factor B-IN-5 (20 and 60 mg/kg; i.g.; twice daily; for 10 weeks) improves interstitial inflammation of renal tubules and reduces kidney damage in male diabetic db/db C57BL/6J mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male diabetic db/db C57BL/6J mice (C57BL/6J-LepR^db/db) (6 weeks)^[1]
Dosage:

20 and 60 mg/kg
Administration:

Oral gavage (i.g.); twice daily for 10 weeks
Result:

Significantly reduced the level of uACR.
Significantly improved renal tubulointerstitial fibrosis and atrophy.
Significantly reduced the thickness of glomerular basement membrane (GBM).
Reduced the expression of inflammatory markers Kim-1 and IL-1β.
Improved mitochondrial morphology and dynamics and upregulated the expression of Mfn2 and Prkn.
Might exert its effect by regulating CASP3 and DPP4.

Chemical Information

CAS No. 1644670-23-4
Masse moléculaire 392.49
Formule C₂₄H₂₈N₂O₃
SMILES

CC1=CC(OC)=C(CN2CC[C@@H](C)C[C@H]2C3=CC=C(C(O)=O)C=C3)C4=C1NC=C4
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Li ZH, et al. A piperidinyl indole derivative, potential complement factor B inhibitor, plays a renoprotective role in diabetic nephropathy. Diabet Med. 2025 Aug;42(8):e70092. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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