Col4a5 - collagen, type IV, alpha 5 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12830

Summary

Predicted to be an extracellular matrix structural constituent. Acts upstream of or within collagen-activated tyrosine kinase receptor signaling pathway and neuromuscular junction development. Located in basement membrane and neuromuscular junction. Part of Collagen type IV trimer. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and spinal cord. Used to study X-linked Alport syndrome. Human ortholog(s) of this gene implicated in Alport syndrome and X-linked Alport syndrome. Orthologous to human COL4A5 (Collagen type IV alpha 5 chain). [provided by Alliance of Genome Resources, Apr 2022]

Col4a5 Products (3)

mRNA Protein Name
NM_001163155.1 NP_001156627.1 collagen alpha-5(IV) chain isoform 1 precursor
NM_001411947.1 NP_001398876.1 collagen alpha-5(IV) chain isoform 2 precursor
NM_007736.4 NP_031762.2 collagen alpha-5(IV) chain isoform 1 precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Références Source
acts upstream of or within collagen-activated tyrosine kinase receptor signaling pathway IGI
IGI: Inferred from genetic interaction
10970885 MGI
acts upstream of or within neuromuscular junction development IMP
IMP: Inferred from mutant phenotype
17418794 MGI
Cellular Component GO Annotation Evidence Références Source
located in basement membrane IDA
IDA: Inferred from direct assay
7885444 MGI
part of collagen type IV trimer IDA
IDA: Inferred from direct assay
12101409 MGI
located in neuromuscular junction IDA
IDA: Inferred from direct assay
7885444 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

collagen alpha-5(IV) chain

  • collagen type IV alpha5 chain

  • procollagen type IV alpha 5

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS02987 COL4A5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19503 Col4a5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25997 Col4a5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Col4a5 NCBI NCBI:1287