Hoxa9 - homeobox A9 Gene

Also Known as D6a9; Hox-1.7

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15405

Summary

This gene is located in a cluster of developmentally and temporally regulated genes on chromosome 6 encoding proteins involved in pattern formation. These proteins contain a characteristic DNA-binding motif called a homeodomain and function in transcriptional regulation. There are four distinct clusters of similar genes on chromosomes 2, 6, 11, and 15. The protein encoded by this gene is important for hematopoeisis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

Hoxa9 Products (2)

mRNA Protein Name
NM_001277238.1 NP_001264167.1 homeobox protein Hox-A9 isoform 2
NM_010456.3 NP_034586.1 homeobox protein Hox-A9 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
17327400 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
IMP: Inferred from mutant phenotype
10082572 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9343407 MGI
Biological Process GO Annotation Evidence Références Source
acts upstream of or within anterior/posterior pattern specification IGI
IGI: Inferred from genetic interaction
8625797 MGI
acts upstream of or within anterior/posterior pattern specification IMP
IMP: Inferred from mutant phenotype
8625797 MGI
acts upstream of or within definitive hemopoiesis IGI
IGI: Inferred from genetic interaction
17761289 MGI
acts upstream of or within embryonic forelimb morphogenesis IGI
IGI: Inferred from genetic interaction
8625797 MGI
acts upstream of or within embryonic skeletal system development IGI
IGI: Inferred from genetic interaction
8625797 MGI
acts upstream of or within embryonic skeletal system development IMP
IMP: Inferred from mutant phenotype
8625797 MGI
acts upstream of or within male gonad development IGI
IGI: Inferred from genetic interaction
23760953 MGI
acts upstream of or within mammary gland development IGI
IGI: Inferred from genetic interaction
9892669 MGI
involved in negative regulation of myeloid cell differentiation IDA
IDA: Inferred from direct assay
11438208 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17327400 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17327400 MGI
acts upstream of or within proximal/distal pattern formation IGI
IGI: Inferred from genetic interaction
8625797 MGI
acts upstream of or within regulation of gene expression IGI
IGI: Inferred from genetic interaction
23760953 MGI
acts upstream of or within single fertilization IGI
IGI: Inferred from genetic interaction
23760953 MGI
acts upstream of or within spermatogenesis IGI
IGI: Inferred from genetic interaction
23760953 MGI
acts upstream of or within uterus development IGI
IGI: Inferred from genetic interaction
23760953 MGI
Cellular Component GO Annotation Evidence Références Source
part of transcription regulator complex IDA
IDA: Inferred from direct assay
9343407 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

homeobox protein Hox-A9

  • homeo box A9

  • homeobox protein Hox-1.7

Hoxa9 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
Hoxa9 P09631 Pbx1 Mus musculus P41778
Y2H Array
20211142
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (17)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-15227 EPZ004777 99.74% Unkown
HY-122623A DB818 dihydrochloride Inducer 99.99% Unkown
HY-100688 ML390 Inhibitor 99.95% Unkown
HY-15222 Menin-MLL inhibitor MI-2 99.41% Unkown
HY-108350 MI-2-2 Inhibitor 99.94% Unkown
HY-15227A EPZ004777 hydrochloride 98.92% Unkown
HY-141716 SW2_110A Inhibitor 99.19% Unkown
HY-101520A Dot1L-IN-1 TFA Inhibitor 99.59% Unkown
HY-124693 DB1055 Inducer / Unkown
HY-RS06303 HOXA9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-101520 Dot1L-IN-1 Inhibitor / Unkown
HY-115619 EPZ004777 formate / Unkown
HY-122698 CCI-007 Activator 98.45% Unkown
HY-15222A Menin-MLL inhibitor MI-2 dihydrochloride / Unkown
HY-155526 FY-21 Inhibitor / Unkown
HY-RS17663 Hoxa9 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24124 Hoxa9 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hoxa9 NCBI NCBI:3205