1. Apoptosis
  2. Apoptosis
  3. CCI-007

CCI-007 

Cat. No.: HY-122698 Purity: 98.45%
Handling Instructions

CCI-007 is a small molecule with cytotoxic activity against infant leukemia with MLL rearrangements, with IC50 values of 2.5-6.2 μM in sensitive cells.

For research use only. We do not sell to patients.

CCI-007 Chemical Structure

CCI-007 Chemical Structure

CAS No. : 939228-52-1

Size Price Stock Quantity
5 mg USD 250 In-stock
Estimated Time of Arrival: December 31
10 mg USD 450 In-stock
Estimated Time of Arrival: December 31
25 mg USD 850 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1350 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1950 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

CCI-007 is a small molecule with cytotoxic activity against infant leukemia with MLL rearrangements, with IC50 values of 2.5-6.2 μM in sensitive cells[1].

In Vitro

CCI-007 is a selective inhibitor of MLL-r, CALM-AF10 and SET-NUP214 leukemia[1].
Following CCI-007 treatment for 24h, significant mitochondrial depolarization was observed in PER-485 cells as evidenced by a shift in JC-1 signal. CCI-007 alters the characteristic MLL-r gene expression signature in sensitive cells with downregulation of the expression of HOXA9, MEIS1, CMYC and BCL2[1].
Resistance to CCI-007 can occur by upregulation of MLL target gene expression[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: PER-485, MOLM-13, MV4;11 cells.
Concentration: 5 μM.
Incubation Time: 24 h.
Result: Induced apoptosis.
Molecular Weight

336.36

Formula

C₁₅H₁₆N₂O₅S

CAS No.
SMILES

O=C(OCC)COC1=CC=C(/C=C(SC(N)=N2)\C2=O)C=C1OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (247.74 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9730 mL 14.8650 mL 29.7301 mL
5 mM 0.5946 mL 2.9730 mL 5.9460 mL
10 mM 0.2973 mL 1.4865 mL 2.9730 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (6.18 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

CCI-007CCI007CCI 007ApoptosisMLL-rCALM-AF10SET-NUP214HOXA9MEIS1CMYCInhibitorinhibitorinhibit

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Product Name:
CCI-007
Cat. No.:
HY-122698
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