1. Epigenetics
  2. Histone Methyltransferase

Dot1L-IN-1 

Cat. No.: HY-101520
Handling Instructions

Dot1L-IN-1 is a highly potent, selective and structurally novel Dot1L inhibitor with a Ki of 2 pM.

For research use only. We do not sell to patients.

Dot1L-IN-1 Chemical Structure

Dot1L-IN-1 Chemical Structure

CAS No. : 2088518-50-5

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Dot1L-IN-1 is a highly potent, selective and structurally novel Dot1L inhibitor with a Ki of 2 pM.

IC50 & Target

Ki: 2 pM (Dot1L)[1]

In Vitro

Dot1L-IN-1 potently suppresses H3K79 dimethylation (IC50 = 3 nM), the direct product of the Dot1Lcatalyzed reaction, as well as the activity of the HoxA9 promoter (IC50 = 17 nM) in HeLa and Molm-13 cells, respectively[1].

Dot1L-IN-1 effectively inhibits proliferation of the human MLL-rearranged leukemia cell line MV4-11 carrying the oncogenic MLL-AF4 fusion (IC50 = 5 nM)[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5475 mL 7.7374 mL 15.4748 mL
5 mM 0.3095 mL 1.5475 mL 3.0950 mL
10 mM 0.1547 mL 0.7737 mL 1.5475 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

646.21

Formula

C₃₂H₃₆ClN₉O₂S

CAS No.

2088518-50-5

SMILES

CC1=NC=CC=C1C2=C(Cl)SC3=CC=C(NC(NCC(NCCCN(C)[[email protected]@H]4CCCN(C5=C(C=CN6)C6=NC=N5)C4)=O)=O)C=C32

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
Dot1L-IN-1
Cat. No.:
HY-101520
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Dot1L-IN-1

Cat. No.: HY-101520