Dot1L-IN-1 TFA
Based on 1 Customer Validation
Dot1L-IN-1 TFA is a highly potent and selective Dot1L inhibitor with a Ki of 2 pM and an IC50 of <0.1 nM. Dot1L-IN-1 TFA potently suppresses H3K79 dimethylation (IC50=3 nM), as well as the activity of the HoxA9 promoter (IC50=17 nM) in HeLa and Molm-13 cells, respectively.
For research use only. We do not sell to patients.
- Purity: 99.59%
- Formula: C34H37ClF3N9O4S
- Molecular Weight:760.23
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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High-Throughput Bioactive Compound Library
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All Histone Methyltransferase Isoforms
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Biological Activity
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DOT1L |
Dot1L-IN-1 (analogue 7) TFA effectively inhibits proliferation of the human MLL-rearranged leukemia cell line MV4-11 carrying the oncogenic MLL-AF4 fusion (IC50=5 nM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Molecular Weight 760.23
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Formula C34H37ClF3N9O4S
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Color Off-white to light yellow
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SMILES
CC1=NC=CC=C1C2=C(Cl)SC3=CC=C(NC(NCC(NCCCN(C)[C@@H]4CCCN(C5=C(C=CN6)C6=NC=N5)C4)=O)=O)C=C32.OC(C(F)(F)F)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (65.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3154 mL | 6.5770 mL | 13.1539 mL | 32.8848 mL |
| 5 mM | 0.2631 mL | 1.3154 mL | 2.6308 mL | 6.5770 mL | |
| 10 mM | 0.1315 mL | 0.6577 mL | 1.3154 mL | 3.2885 mL | |
| 15 mM | 0.0877 mL | 0.4385 mL | 0.8769 mL | 2.1923 mL | |
| 20 mM | 0.0658 mL | 0.3288 mL | 0.6577 mL | 1.6442 mL | |
| 25 mM | 0.0526 mL | 0.2631 mL | 0.5262 mL | 1.3154 mL | |
| 30 mM | 0.0438 mL | 0.2192 mL | 0.4385 mL | 1.0962 mL | |
| 40 mM | 0.0329 mL | 0.1644 mL | 0.3288 mL | 0.8221 mL | |
| 50 mM | 0.0263 mL | 0.1315 mL | 0.2631 mL | 0.6577 mL | |
| 60 mM | 0.0219 mL | 0.1096 mL | 0.2192 mL | 0.5481 mL |
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