IRGM - immunity related GTPase M Gene

Also Known as IFI1; IRGM1; LRG47; LRG-47

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 345611

About IRGM

Cytogenetic location: 5q33.1 Genomic coordinates (GRCh38): 5:150,846,521-150,902,402 (from NCBI)

This gene has 3 transcripts (splice variants), 360 orthologues, 1 paralogue and is associated with 3 phenotypes. Low expression observed in reference dataset.

Summary

This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating Autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2016]

IRGM Products (2)

mRNA	Protein	Name
NM_001145805.2	NP_001139277.1	immunity-related GTPase family M protein isoform 2
NM_001346557.2	NP_001333486.1	immunity-related GTPase family M protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables BH3 domain binding	IMP IMP: Inferred from mutant phenotype	25891078	GOA
enables CARD domain binding	IMP IMP: Inferred from mutant phenotype	25891078	GOA
enables G protein activity	IDA IDA: Inferred from direct assay	30612879	GOA
enables GTPase activity	IDA IDA: Inferred from direct assay	29420192	GOA
enables cardiolipin binding	IDA IDA: Inferred from direct assay	21102437	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25891078	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	25891078	GOA
enables protein serine/threonine kinase activator activity	IDA IDA: Inferred from direct assay	25891078	GOA
enables protein serine/threonine kinase activator activity	IMP IMP: Inferred from mutant phenotype	28389568	GOA
enables protein-macromolecule adaptor activity	IDA IDA: Inferred from direct assay	25891078	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in CAMKK-AMPK signaling cascade	IMP IMP: Inferred from mutant phenotype	25891078	GOA
involved in autophagosome assembly	IMP IMP: Inferred from mutant phenotype	16888103	GOA
involved in cellular response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	25891078	GOA
involved in cellular response to virus	IMP IMP: Inferred from mutant phenotype	28389568	GOA
involved in defense response to Gram-negative bacterium	IMP IMP: Inferred from mutant phenotype	25891078	GOA
involved in defense response to bacterium	IDA IDA: Inferred from direct assay	25891078	GOA
involved in defense response to bacterium	IMP IMP: Inferred from mutant phenotype	16888103	GOA
involved in innate immune response	IMP IMP: Inferred from mutant phenotype	16888103	GOA
involved in negative regulation of NLRP3 inflammasome complex assembly	IDA IDA: Inferred from direct assay	30612879	GOA
involved in negative regulation of cGAS/STING signaling pathway	IDA IDA: Inferred from direct assay	32715615	GOA
involved in negative regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	36221902	GOA
involved in negative regulation of defense response to virus	IDA IDA: Inferred from direct assay	34467632	GOA
involved in negative regulation of inflammatory response	IDA IDA: Inferred from direct assay	30612879	GOA
involved in negative regulation of type I interferon production	IDA IDA: Inferred from direct assay	32715615	GOA
involved in nucleotide-binding oligomerization domain containing 2 signaling pathway	IMP IMP: Inferred from mutant phenotype	25891078	GOA
involved in positive regulation of autophagosome maturation	IMP IMP: Inferred from mutant phenotype	16888103	GOA
involved in positive regulation of autophagy	IDA IDA: Inferred from direct assay	25891078	GOA
involved in positive regulation of autophagy	IMP IMP: Inferred from mutant phenotype	16888103	GOA
involved in positive regulation of lysosome organization	IDA IDA: Inferred from direct assay	32753672	GOA
involved in positive regulation of mitochondrial fission	IDA IDA: Inferred from direct assay	21102437	GOA
involved in positive regulation of mitophagy	IDA IDA: Inferred from direct assay	21102437	GOA
involved in positive regulation of peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	25891078	GOA
involved in positive regulation of peptidyl-threonine phosphorylation	IMP IMP: Inferred from mutant phenotype	25891078	GOA
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	28389568	GOA
involved in positive regulation of protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	28389568	GOA
involved in positive regulation of type II interferon-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	16888103	GOA
involved in positive regulation of xenophagy	IDA IDA: Inferred from direct assay	25891078	GOA
involved in protein destabilization	IMP IMP: Inferred from mutant phenotype	25891078	GOA
involved in protein lipidation involved in autophagosome assembly	IMP IMP: Inferred from mutant phenotype	28389568	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	25891078	GOA
involved in protein targeting to vacuole involved in autophagy	IDA IDA: Inferred from direct assay	29420192	GOA
involved in protein-containing complex assembly	IDA IDA: Inferred from direct assay	25891078	GOA
involved in regulation of protein complex stability	IMP IMP: Inferred from mutant phenotype	25891078	GOA
involved in regulation of protein-containing complex assembly	IMP IMP: Inferred from mutant phenotype	25891078	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	28389568	GOA
located in Golgi membrane	IDA IDA: Inferred from direct assay	28389568	GOA
is active in autophagosome membrane	IDA IDA: Inferred from direct assay	30612879	GOA
located in cytosol	IDA IDA: Inferred from direct assay	25891078	GOA
is active in mitochondrion	IDA IDA: Inferred from direct assay	21102437	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	25891078	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IRGM Protein Structure

IIGP

0
100
181 a.a.

Protein Preferred Names	Protein Names
immunity-related GTPase family M protein	LPS-stimulated RAW 264.7 macrophage protein 47 homolog

IRGM Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	IRGM	A1A4Y4	OPTN	Homo sapiens	Q96CV9	Validated Y2H	32814053
Intra	IRGM	A1A4Y4	OPTN	Homo sapiens	Q96CV9	Y2H Array	32814053
Intra	IRGM	A1A4Y4	OPTN	Homo sapiens	Q96CV9	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Inflammatory Bowel Disease 19	Inflammatory Bowel Disease 19 IBD19 Bowel Disease, Inflammatory, Type 19
Crohn'S Disease	Crohn Disease Pediatric Crohn'S Disease Regional Enteritis Crohn'S Disease Of Large Bowel Granulomatous Colitis Enteritis, Granulomatous Enteritis Crohn'S Disease Of Colon Colitis, Granulomatous Crohn'S Enteritis Enteritis, Regional Ileitis Adenoviral Enteritis Acute Gastroenteropathy Due To Norwalk Agent Viral Gastroenteritis Due To Norwalk Agent Winter Vomiting Epidemic Winter Vomiting Disease Small Round Structured Virus Enteritis Epidemic Vomiting Syndrome Epidemic Vomiting Epidemic Nausea Epidemic Viral Gastroenteritis Due To Norwalk Virus Noroviral Enteritis Crohn Disease Nos Crohns Cd - [Crohn'S Disease] Regional Enteritis Of Bowel Crohn'S Regional Enteritis Cobble-Stone Appearance Of Intestine Intestinal Ulcer And Erosion Due To Crohn Disease Granulomatous Enteritis
Colitis
Ulcerative Colitis	Colitis Gravis Left Sided Ulcerative Colitis Left-Sided Ulcerative Colitis Idiopathic Proctocolitis Inflammatory Bowel Disease, Ulcerative Colitis Type Uc Colitis Ulcerative Colitis, Ulcerative Chronic Left-Sided Ulcerative Colitis Uc - [Ulcerative Colitis] Chronic Ulcerative Enteritis Mucosal Proctocolitis Ulcerative Mucosal Proctocolitis Left Hemicolitis
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Inflammatory Bowel Disease 5	IBD5
Inflammatory Bowel Disease 1	Inflammatory Bowel Disease 1 IBD1 Crohn Disease-Associated Growth Failure Crohn Disease Regional Enteritis Ulcerative Colitis Crohn Disease-Associated Growth Failure, Susceptibility To Inflammatory Bowel Disease 1, Crohn Disease Bowel Disease, Inflammatory, Type 1
Crohn'S Colitis	Crohn Disease
Ileitis	Crohn'S Ileitis
Autoimmune Disease Of Gastrointestinal Tract
Leprosy 3	Leprosy Leprosy, Susceptibility To, 3 Hansen'S Disease Leprosy, Susceptibility To Hansen Disease Infection Due To Mycobacterium Leprae LPRS3 Leprosy, Type 3 Anaesthesia Leprosy Anaesthetic Leprosy Maculoanaesthetic Leprosy Macular Leprosy Leprosy Unspecified

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS06915	IRGM Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27268	Irgm Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	IRGM	RGD	RGD:1305163
Others	IRGM	NCBI