NCGC00092410
Based on 1 Customer Validation
NCGC00092410 is a potent, selective, and nonsugar glucocerebrosidase (GC) inhibitor, with an IC50 of 31 nM. NCGC00092410 shows no activity against the related hydrolases at concentrations up to 77 μM. NCGC00092410, a GC chaperone, and increases the activity and lysosomal localization of glucocerebrosidase in mutant cell lines. NCGC00092410 can be used for the research of Gaucher disease.
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- Pureté: 98.10%
- CAS No.: 442898-34-2
- Formule: C21H27N3O2
- Masse moléculaire:353.46
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
IC50: 31 nM (glucocerebrosidase)[1]
NCGC00092410 (7.3-130 nM; 25 min) inhibits the GC activity at various substrate concentrations (10-150 μM) in a dose-dependent manner[1].
NCGC00092410 (55-40 μM; 2 d) increases the GC activity in the N370S mutant fibroblasts[1].
NCGC00092410 (40 μM; 60-72 h) increases the lysosomal localization of GC in gaucher fibroblasts[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 442898-34-2
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Appearance Solid
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Masse moléculaire 353.46
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Formule C21H27N3O2
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Color Light yellow to yellow
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SMILES
O=C(C1CCCCC1)NC2=CC=C3N=C(N4CCOCC4)C=C(C)C3=C2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Solvant et solubilité
DMSO : 41.67 mg/mL (117.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
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Fiche technique (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8292 mL | 14.1459 mL | 28.2917 mL | 70.7294 mL |
| 5 mM | 0.5658 mL | 2.8292 mL | 5.6583 mL | 14.1459 mL | |
| 10 mM | 0.2829 mL | 1.4146 mL | 2.8292 mL | 7.0729 mL | |
| 15 mM | 0.1886 mL | 0.9431 mL | 1.8861 mL | 4.7153 mL | |
| 20 mM | 0.1415 mL | 0.7073 mL | 1.4146 mL | 3.5365 mL | |
| 25 mM | 0.1132 mL | 0.5658 mL | 1.1317 mL | 2.8292 mL | |
| 30 mM | 0.0943 mL | 0.4715 mL | 0.9431 mL | 2.3576 mL | |
| 40 mM | 0.0707 mL | 0.3536 mL | 0.7073 mL | 1.7682 mL | |
| 50 mM | 0.0566 mL | 0.2829 mL | 0.5658 mL | 1.4146 mL | |
| 60 mM | 0.0472 mL | 0.2358 mL | 0.4715 mL | 1.1788 mL | |
| 80 mM | 0.0354 mL | 0.1768 mL | 0.3536 mL | 0.8841 mL | |
| 100 mM | 0.0283 mL | 0.1415 mL | 0.2829 mL | 0.7073 mL |
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