Oseltamivir-d5
Based on 1 Customer Validation
Oseltamivir-d5 is the deuterium labeled Oseltamivir. Oseltamivir is an influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC50 of 0.67, 0.9, 1.34 and 13 nM, respectively. Anti-influenza A and B agent.
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- CAS No.: 1093851-63-8
- Formule: C16H23D5N2O4
- Masse moléculaire:317.44
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Stockage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1093851-63-8
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Unlabeled Cas 196618-13-0
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Appearance Solid
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Masse moléculaire 317.44
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Formule C16H23D5N2O4
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Color White to off-white
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SMILES
CCC(CC)O[C@H]1[C@@H]([C@H](CC(C(OC(C([2H])([2H])[2H])([2H])[2H])=O)=C1)N)NC(C)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvant et solubilité
DMSO : 104 mg/mL (327.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. O Ferraris, et al. Sensitivity of Influenza Viruses to Zanamivir and Oseltamivir: A Study Performed on Viruses Circulating in France Prior to the Introduction of Neuraminidase Inhibitors in Clinical Practice. Antiviral Res. 2005 Oct;68(1):43-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1502 mL | 15.7510 mL | 31.5020 mL | 78.7550 mL |
| 5 mM | 0.6300 mL | 3.1502 mL | 6.3004 mL | 15.7510 mL | |
| 10 mM | 0.3150 mL | 1.5751 mL | 3.1502 mL | 7.8755 mL | |
| 15 mM | 0.2100 mL | 1.0501 mL | 2.1001 mL | 5.2503 mL | |
| 20 mM | 0.1575 mL | 0.7876 mL | 1.5751 mL | 3.9378 mL | |
| 25 mM | 0.1260 mL | 0.6300 mL | 1.2601 mL | 3.1502 mL | |
| 30 mM | 0.1050 mL | 0.5250 mL | 1.0501 mL | 2.6252 mL | |
| 40 mM | 0.0788 mL | 0.3938 mL | 0.7876 mL | 1.9689 mL | |
| 50 mM | 0.0630 mL | 0.3150 mL | 0.6300 mL | 1.5751 mL | |
| 60 mM | 0.0525 mL | 0.2625 mL | 0.5250 mL | 1.3126 mL | |
| 80 mM | 0.0394 mL | 0.1969 mL | 0.3938 mL | 0.9844 mL | |
| 100 mM | 0.0315 mL | 0.1575 mL | 0.3150 mL | 0.7876 mL |
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