5-Carboxamido-1,3,2-dioxaphosphorinanes, potent inhibitors of MTP

  • Bioorg Med Chem Lett. 2004 Oct 18;14(20):5067-70. doi: 10.1016/j.bmcl.2004.07.069.
Richard Sulsky  1 ,  Jeffrey A Robl ,  Scott A Biller ,  Thomas W Harrity ,  John Wetterau ,  Fergal Connolly ,  Kern Jolibois ,  Lori Kunselman
Affiliations
  • 1. Department of Discovery Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000, USA. [email protected]
PMID: 15380200 DOI: 10.1016/j.bmcl.2004.07.069
Abstract

5-Carboxamido-1,3,2-dioxaphosphorinanes have been identified as potent inhibitors of microsomal triglyceride-transfer protein. The 1,3,2-dioxaphosphorine functionality acted as a neutral and stable replacement for piperidine and piperidine N-oxide.

Products