Sitagliptin fenilalanil
Based on 1 publication(s) in Google Scholar
Sitagliptin fenilalanil is a dipeptidyl aminopeptidase 4 (DPP-4) inhibitor.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 99.57%
- CAS No.: 1339955-03-1
- Formule: C25H24F6N6O2
- Masse moléculaire:554.49
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Metabolism/Protease Compound Library
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Metabolic Enzyme Compound Library
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Publications Citing Use of MedChemExpress (MCE) Sitagliptin fenilalanil
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Activité biologique
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DPP-4 |
Chemical Information
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CAS No. 1339955-03-1
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Appearance Solid
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Masse moléculaire 554.49
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Formule C25H24F6N6O2
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Color White to off-white
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SMILES
FC(F)(C1=NN=C2N1CCN(C(C[C@H](NC([C@@H](N)CC3=CC=CC=C3)=O)CC4=C(C=C(C(F)=C4)F)F)=O)C2)F
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Biochem Pharmacol
2025 Oct 23:117451. PMID: 41138926
Solvant et solubilité
DMSO : 250 mg/mL (450.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (3.75 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
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Fiche technique (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8035 mL | 9.0173 mL | 18.0346 mL | 45.0865 mL |
| 5 mM | 0.3607 mL | 1.8035 mL | 3.6069 mL | 9.0173 mL | |
| 10 mM | 0.1803 mL | 0.9017 mL | 1.8035 mL | 4.5086 mL | |
| 15 mM | 0.1202 mL | 0.6012 mL | 1.2023 mL | 3.0058 mL | |
| 20 mM | 0.0902 mL | 0.4509 mL | 0.9017 mL | 2.2543 mL | |
| 25 mM | 0.0721 mL | 0.3607 mL | 0.7214 mL | 1.8035 mL | |
| 30 mM | 0.0601 mL | 0.3006 mL | 0.6012 mL | 1.5029 mL | |
| 40 mM | 0.0451 mL | 0.2254 mL | 0.4509 mL | 1.1272 mL | |
| 50 mM | 0.0361 mL | 0.1803 mL | 0.3607 mL | 0.9017 mL | |
| 60 mM | 0.0301 mL | 0.1503 mL | 0.3006 mL | 0.7514 mL | |
| 80 mM | 0.0225 mL | 0.1127 mL | 0.2254 mL | 0.5636 mL | |
| 100 mM | 0.0180 mL | 0.0902 mL | 0.1803 mL | 0.4509 mL |
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