Trk-IN-10
Trk-IN-10 (Compound 14j) is a potent inhibitor of TRK (IC50 = 0.86, 6.92 nM, against TrkA, TrkAG595R, respectively). As a receptor tyrosine kinase (RTK), tropomyosin receptor kinase (Trk) is a key agent target in solid tumors. Trk-IN-10 (IC50 = 350 nM against ALK) has a higher selectivity of Trk inhibition, which may be of great significance for reducing toxicity.
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- CAS No.: 2700265-61-6
- Formule: C20H20FN5O3
- Masse moléculaire:397.40
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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TrkA |
Chemical Information
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CAS No. 2700265-61-6
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Masse moléculaire 397.40
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Formule C20H20FN5O3
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SMILES
C[C@H]1CNC(C2=C3N=C4C(OC[C@H](N4CC5=CC=C(C=C5O1)F)C)=CN3N=C2)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Trk-IN-10 Related Classifications
HY-144423 Related Classifications
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