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Cat. No.: HY-153501

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TrkA-IN-5

TrkA-IN-5 is a TrkA inhibitor with an IC₅₀ value of 1.678 nM against TrkA. TrkA-IN-5 can be used in cancer research.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 1377503-70-2
Formule: C₂₅H₁₈F₃N₅O₂S
Masse moléculaire:509.51

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

TrkA-IN-5 Chemical Structure

CAS No.: 1377503-70-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

TrkA-IN-5 is a TrkA inhibitor with an IC₅₀ value of 1.678 nM against TrkA. TrkA-IN-5 can be used in cancer research^[1].

IC₅₀ & Target^[1]

TrkA

1.678 nM (IC₅₀)

Voir tous les produits spécifiques à Isoform Trk Receptor :

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	GI	40 % Compound: 6t	Cytotoxicity against human MCF7 cells assessed as growth inhibition at 0.1 to 50 uM after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as growth inhibition at 0.1 to 50 uM after 48 hrs by MTT assay	[PMID: 22575050]
MCF7	IC₅₀	4.2 μM Compound: 6t	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 22575050]

In Vitro

TrkA-IN-5 (Compound 20) potently inhibits human TrkA (PDB ID: 4aoj) with an IC₅₀ value of 1.678 nM. It forms multiple stable hydrogen bonds and hydrophobic interactions with the active site of this protein, and its activity can be accurately predicted by CoMFA and CoMSIA 3D-QSAR models^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1377503-70-2
Masse moléculaire 509.51
Formule C₂₅H₁₈F₃N₅O₂S
SMILES

O=S(=O)(NC1=CC(N)=CC(=C1)C2=CN=C3NC=C(C=4C=CN=CC4)C3=C2)C=5C=CC=C(C5)C(F)(F)F
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Adnane Aouidate, et al. Molecular Docking and 3D-QSAR Studies on 7-azaindole Derivatives as
Inhibitors of Trk A: A Strategic Design in Novel Anticancer Agents. Letters in Drug Design & Discovery, 2018, 15, 1211-1223.

Calculators

Calculateur de molarité

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Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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TrkA-IN-5

Voir tous les produits spécifiques à Isoform Trk Receptor

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

TrkA-IN-5 Related Classifications

HY-153501 Related Classifications