147318-81-8
Chemical Structure
Kynostatin 272
Synonym(s): KNI 272; Kynostatin; NSC 651714
- CAS No.: 147318-81-8
- Formula:C33H41N5O6S2
- Molecular Weight:667.84
IUPAC Name: (R)-N-(tert-butyl)-3-((2S,3S)-2-hydroxy-3-((R)-2-(2-(isoquinolin-5-yloxy)acetamido)-3-(methylthio)propanamido)-4-phenylbutanoyl)thiazolidine-4-carboxamide
InChIKey: NJBBLOIWMSYVCQ-VZTVMPNDSA-N
SMILES: O=C(N1[C@@H](CSC1)C(NC(C)(C)C)=O)[C@@H](O)[C@H](CC2=CC=CC=C2)NC([C@H](CSC)NC(COC3=C4C(C=NC=C4)=CC=C3)=O)=O
Biological Activity: Kynostatin 272 (KNI 272) is a potent HIV protease inhibitor. Kynostatin 272 inhibits the activity of the HIV protease by simulating the substrate transition state of the HIV protease, thus preventing a key step in the replication of the HIV virus. Kynostatin 272 provides an important research foundation for the development of drugs for HIV and AIDS[1][2].
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Kynostatin 272 | Kynostatin 272 (KNI 272) is a potent HIV protease inhibitor. Kynostatin 272 inhibits the activity of the HIV protease by simulating the substrate transition state of the HIV protease, thus preventing a key step in the replication of the HIV virus. Kynostatin 272 provides an important research foundation for the development of drugs for HIV and AIDS. | |||||||||||||||||||||
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- [1]. Kimura T, et al. Rigid backbone moiety of KNI-272, a highly selective HIV protease inhibitor: methanol, acetone and dimethylsulfoxide solvated forms of 3-[3-benzyl-2-hydroxy-9-(isoquinolin-5-yloxy)-6-methylsulfanylmethyl-5, 8-dioxo-4, 7-diazanonanoyl]-N-tert-butyl-1, 3-thiazolidine-4-carboxamide[J]. Acta Crystallographica Section B: Structural Science, 2004, 60(4): 433-437.
- [2]. Freedberg D I, et al. Flexibility and function in HIV protease: Dynamics of the HIV-1 protease bound to the asymmetric inhibitor kynostatin 272 (KNI-272)[J]. Journal of the American Chemical Society, 1998, 120(31): 7916-7923.
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