1964516-59-3
Chemical Structure
NCATS-SM1440
- CAS No.: 1964516-59-3
- Formula:C30H22F2N4O4S3
- Molecular Weight:636.71
InChIKey: WGFNHVCWSDXXPH-UHFFFAOYSA-N
SMILES: O=C(C1=CSC(N2N=C(C(CC3=CC=C(S(=O)(N)=O)C(F)=C3)=C2CC4CC4)C5=CC(C#CC6=CC=CS6)=C(F)C=C5)=N1)O
Biological Activity: NCATS-SM1440 is a glycolysis inhibitor and metabolic regulator that targets LDHA and LDHB (IC50=0.06 μM and 0.03 μM, respectively). Upon binding to LDHA, NCATS-SM1440 blocks the glycolysis pathway and reduces lactate production. NCATS-SM1440 drives the shift of pyruvate metabolism toward mitochondrial metabolism, effectively disrupting the dependence of cancer cells on aerobic glycolysis. NCATS-SM1440 can be widely used in research related to cancer, Ewing's sarcoma, and other related conditions[1][2][3].
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NCATS-SM1440 | NCATS-SM1440 is a glycolysis inhibitor and metabolic regulator that targets LDHA and LDHB (IC50=0.06 μM and 0.03 μM, respectively). Upon binding to LDHA, NCATS-SM1440 blocks the glycolysis pathway and reduces lactate production. NCATS-SM1440 drives the shift of pyruvate metabolism toward mitochondrial metabolism, effectively disrupting the dependence of cancer cells on aerobic glycolysis. NCATS-SM1440 can be widely used in research related to cancer, Ewing's sarcoma, and other related conditions. | |||||||||||||||||||||
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- [1]. Puxeddu M, et al. Metabolism, a Blossoming Target for Small-Molecule Anticancer Drugs. Molecules. 2025;30(17):3457. Published 2025 Aug 22. [Content Brief]
- [2]. Pan W, Tao C, Wu Y, et al. A medicinal chemistry perspective on lactate dehydrogenase: current status and future directions[J]. Journal of Medicinal Chemistry, 2025, 68(16): 16869-16900.
- [3]. Masci D, et al. Metabolic Rewiring in Cancer: Small Molecule Inhibitors in Colorectal Cancer Therapy. Molecules. 2024;29(9):2110. Published 2024 May 2. [Content Brief]
Keywords
