1965327-09-6
1965327-09-6
Chemical Structure
Tiancimycin A
Synonym(s): TNM A
- CAS No.: 1965327-09-6
- Formula:C27H19NO8
- Molecular Weight:485.44
InChIKey: DJOMZYYFFHCVSQ-PUMJXKNOSA-N
SMILES: C[C@H]([C@@]12[C@]3(O2)C4=CC(O)=C(C(C5=CC=C6OC)=O)C(C(C5=C6O)=O)=C4N[C@@]1([H])C#CC=CC#C[C@H]3O)O
Biological Activity: Tiancimycin A (TNM A) is an anticancer agent. Tiancimycin A induces rapid DNA damage, cell cycle arrest, and apoptosis. Tiancimycin A can be isolated from Streptomyces sp. CB03234[1][2].
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Tiancimycin A | Tiancimycin A (TNM A) is an anticancer agent. Tiancimycin A induces rapid DNA damage, cell cycle arrest, and apoptosis. Tiancimycin A can be isolated from Streptomyces sp. CB03234. | |||||||||||||||||||||
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References
- [1]. Feng X, et al. Liposome-Encapsulated Tiancimycin A Is Active against Melanoma and Metastatic Breast Tumors: The Effect of cRGD Modification of the Liposomal Carrier and Tiancimycin A Dose on Drug Activity and Toxicity. Mol Pharm. 2022 Apr 4;19(4):1078-1090. [Content Brief]
- [2]. Liu L,et al. Ribosome engineering and fermentation optimization leads to overproduction of tiancimycin A, a new enediyne natural product from Streptomyces sp. CB03234. J Ind Microbiol Biotechnol. 2018 Mar;45(3):141-151. [Content Brief]
Keywords
