19982-08-2
19982-08-2
Chemical Structure
Memantine
- CAS No.: 19982-08-2
- Formula:C12H21N
- Molecular Weight:179.30
IUPAC Name: (1r,3R,5S,7r)-3,5-dimethyladamantan-1-amine
InChIKey: BUGYDGFZZOZRHP-CDECOKDKSA-N
SMILES: N[C@]12C[C@@]3(C)C[C@](C2)(C)C[C@@H](C1)C3
Biological Activity: Memantine is an orally active, noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist. Memantine can be used for the research of moderate-to-severe Alzheimer's disease (AD)[1][2][3].
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Memantine | 99.89% | Memantine is an orally active, noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist. Memantine can be used for the research of moderate-to-severe Alzheimer's disease (AD). | ||||||||||||||||||||
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Memantine-d3 hydrochloride | Memantine-d3 (hydrochloride) is deuterium labeled Memantine. Memantine is an orally active, noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist. Memantine can be used for the research of moderate-to-severe Alzheimer's disease (AD). | |||||||||||||||||||||
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References
- [1]. Marotta G, et al. Memantine Derivatives as Multitarget Agents in Alzheimer's Disease. Molecules. 2020;25(17):4005. Published 2020 Sep 2. [Content Brief]
- [2]. Pinho J, et al. Enhanced LTP in aged rats: Detrimental or compensatory?. Neuropharmacology. 2017;114:12-19. [Content Brief]
- [3]. Moriguchi S, et al. Memantine Improves Depressive-like Behaviors via Kir6.1 Channel Inhibition in Olfactory Bulbectomized Mice. Neuroscience. 2020;442:264-273. [Content Brief]
Keywords
