6472-91-9
6472-91-9
Chemical Structure
Chrysamine G
- CAS No.: 6472-91-9
- Formula:C26H16N4Na2O6
- Molecular Weight:526.41
IUPAC Name: sodium 5,5'-((1E,1'E)-[1,1'-biphenyl]-4,4'-diylbis(diazene-2,1-diyl))bis(2-hydroxybenzoate)
InChIKey: AZOPGDOIOXKJRA-ZQGAZYNISA-L
SMILES: O=C(O[Na])C1=C(O)C=CC(/N=N/C2=CC=C(C3=CC=C(/N=N/C4=CC(C(O[Na])=O)=C(O)C=C4)C=C3)C=C2)=C1
Biological Activity: Chrysamine G, a carboxylic acid analogue of Congo Red, can be used as a probe of amyloid deposition in Alzheimer's disease. Chrysamine G also can inhibit Aβ-induced toxicity in PC12 cells[1][2].
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Chrysamine G | Chrysamine G, a carboxylic acid analogue of Congo Red, can be used as a probe of amyloid deposition in Alzheimer's disease. Chrysamine G also can inhibit Aβ-induced toxicity in PC12 cells. | |||||||||||||||||||||
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References
- [1]. Klunk WE, et, al. Chrysamine-G binding to Alzheimer and control brain: autopsy study of a new amyloid probe. Neurobiol Aging. Jul-Aug 1995;16(4):541-8. [Content Brief]
- [2]. Klunk WE, et, al. Chrysamine-G, a lipophilic analogue of Congo red, inhibits A beta-induced toxicity in PC12 cells. Life Sci. 1998;63(20):1807-14. [Content Brief]
Keywords
