78654-44-1
Chemical Structure
Amicoumacin A
- CAS No.: 78654-44-1
- Formula:C20H29N3O7
- Molecular Weight:423.46
IUPAC Name: (2S,3S,4S)-4-amino-2,3-dihydroxy-N1-((S)-1-((S)-8-hydroxy-1-oxoisochroman-3-yl)-3-methylbutyl)hexanediamide
InChIKey: DCPWYLSPIAHJFU-YKRRISCLSA-N
SMILES: O=C1C2=C(O)C=CC=C2C[C@@](O1)([H])[C@H](CC(C)C)NC([C@@H](O)[C@@H](O)[C@@H](N)CC(N)=O)=O
Biological Activity: Amicoumacin A is an orally active antibiotic. Amicoumacin A targets bacterial ribosomes and inhibits bacterial translation by stabilizing the interaction between mRNA and ribosomes. Amicoumacin A induces cancer cell death by targeting eukaryotic ribosomes. Amicoumacin A exhibits anti-inflammatory and anti-ulcer activities, inhibits carrageenan-induced paw edema, and prevents stress-induced gastric ulcers. Amicoumacin A inhibits the growth of Gram-positive bacteria, Salmonella spp., Shigella spp., Helicobacter pylori, and methicillin-resistant Staphylococcus aureus. Amicoumacin A can be used in the research of lung cancer, breast cancer, bacterial infections, inflammatory edema and gastric ulcers[1][2][3][4][5].
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Amicoumacin A | Amicoumacin A is an orally active antibiotic. Amicoumacin A targets bacterial ribosomes and inhibits bacterial translation by stabilizing the interaction between mRNA and ribosomes. Amicoumacin A induces cancer cell death by targeting eukaryotic ribosomes. Amicoumacin A exhibits anti-inflammatory and anti-ulcer activities, inhibits carrageenan-induced paw edema, and prevents stress-induced gastric ulcers. Amicoumacin A inhibits the growth of Gram-positive bacteria, Salmonella spp., Shigella spp., Helicobacter pylori, and methicillin-resistant Staphylococcus aureus. Amicoumacin A can be used in the research of lung cancer, breast cancer, bacterial infections, inflammatory edema and gastric ulcers. | |||||||||||||||||||||
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- [1]. Prokhorova IV, et al. Amicoumacin A induces cancer cell death by targeting the eukaryotic ribosome. Sci Rep. 2016;6:27720. Published 2016 Jun 14. [Content Brief]
- [3]. Maksimova EM, et al. Multifaceted Mechanism of Amicoumacin A Inhibition of Bacterial Translation. Front Microbiol. 2021;12:618857. Published 2021 Feb 12. [Content Brief]
- [4]. Polikanov YS, et al. Amicoumacin a inhibits translation by stabilizing mRNA interaction with the ribosome. Mol Cell. 2014;56(4):531-540. [Content Brief]
- [5]. Itoh J, et al. Amicoumacin-A, a new antibiotic with strong antiinflammatory and antiulcer activity. J Antibiot (Tokyo). 1981 May;34(5):611-3. [Content Brief]
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