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ATP11B - ATPase phospholipid transporting 11B (putative) Gene

Also Known as ATPIF; ATPIR

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23200

About ATP11B

Cytogenetic location: 3q26.33 Genomic coordinates (GRCh38): 3:182,793,504-182,921,629 (from NCBI)

This gene has 10 transcripts (splice variants), 225 orthologues and 13 paralogues. Ubiquitous expression in esophagus (RPKM 12.0), bone marrow (RPKM 11.3) and 25 other tissues.

Summary

P-type ATPases, such as ATP11B, are phosphorylated in their intermediate state and drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified. One subfamily transports heavy metal ions, such as Cu(2+) or Cd(2+). Another subfamily transports non-heavy metal ions, such as H(+), Na(+), K(+), or CA(+). A third subfamily transports amphipaths, such as phosphatidylserine.[supplied by OMIM, Feb 2005]

ATP11B Products (1)

mRNA	Protein	Name
NM_014616.3	NP_055431.1	phospholipid-transporting ATPase IF

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21914794	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in early endosome membrane	IDA IDA: Inferred from direct assay	31571211	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	21914794	GOA
located in membrane	IPI IPI: Inferred from physical interaction	31571211	GOA
part of phospholipid-translocating ATPase complex	IPI IPI: Inferred from physical interaction	31571211	GOA
located in recycling endosome	IDA IDA: Inferred from direct assay	21914794	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATP11B Protein Structure

E1-E2_ATPase

Hydrolase

0
200
400
600
800
1000
1177 a.a.

Protein Preferred Names	Protein Names
phospholipid-transporting ATPase IF	ATPase IR

ATP11B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	ATP11B	Q9Y2G3	IFNA21	Homo sapiens	P01568	Anti Tag CoIP	33961781
Intra	ATP11B	Q9Y2G3	IFNA21	Homo sapiens	P01568	Anti Tag CoIP	28514442
Intra	ATP11B	Q9Y2G3	TMEM30A	Homo sapiens	Q9NV96	Anti Tag CoIP	31571211

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Hypoparathyroidism, X-Linked	HYPX X-Linked Hypoparathyroidism Parathyroid Glands, Agenesis Of Agenesis Of Parathyroid Glands Hypoparathyroidism X-Linked Hypoparathyroidism - X-Linked
Cerebellar Ataxia, Mental Retardation, And Dysequilibrium Syndrome 1	Dysequilibrium Syndrome CAMRQ1 Des Cerebellar Ataxia, Intellectual Disability, And Dysequilibrium Syndrome 1 Cerebellar Hypoplasia, Vldlr-Associated Cerebellar Hypoplasia And Mental Retardation With Or Without Quadrupedal Locomotion 1 Cerebellar Ataxia, Mental Retardation And Dysequlibrium Syndrome Uner Tan Syndrome Vldlr Cerebellar Hypoplasia Vldlrch Vldlr-Associated Cerebellar Hypoplasia Cerebellar Ataxia And Mental Retardation With Or Without Quadrupedal Locomotion 1 Cerebellar Ataxia, Congenital, And Mental Retardation, Autosomal Recessive Camrq Cerebellar Ataxia, Mental Retardation, Dysequilibrium Syndrome 1 Cerebellar Disorder, Nonprogressive, With Intellectual Disability Cerebellar Hypoplasia, Vldlr Associated Autosomal Recessive Cerebellar Ataxia With Mental Retardation Autosomal Recessive Cerebellar Hypoplasia With Cerebral Gyral Simplification Cerebellar Disorder, Nonprogressive, With Mental Retardation Cerebellar Hypoplasia And Mental Retardation With Or Without Quadrupedal Locomotion Chmrq1 Des-Vldlr Dysequilibrium Syndrome-Vldlr Vldlr-Ch Camrq Syndrome Cerebellar Ataxia-Intellectual Disability-Dysequilibrium Syndrome Syndrome Non-Progressive Cerebellar Ataxia-Intellectual Disability Syndrome Uts Cerebellar Hypoplasia Vldlr-Associated Dialysis Disequilibrium Syndrome
Cholestasis, Progressive Familial Intrahepatic, 1	PFIC1 Byler Disease Cholestasis, Progressive Familial Intrahepatic 1 Progressive Familial Intrahepatic Cholestasis 1 Progressive Familial Intrahepatic Cholestasis Type 1 Fic1 Deficiency Byler'S Disease Cholestasis, Fatal Intrahepatic Progressive Familial Intrahepatic Cholestasis Severe Atp8b1 Deficiency Fatal Intrahepatic Cholestasis Cholestasis, Intrahepatic, Familial, Progressive, Type 1 Progressive Intrahepatic Cholestasis Cholestasis, Progressive Familial Intrahepatic 3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS01175	ATP11B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21821	Atp11b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28338	Atp11b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ATP11B	VGNC	VGNC:102600
Macaca mulatta	ATP11B	VGNC	VGNC:84236
Rattus norvegicus	ATP11B	RGD	RGD:1561719
Mus musculus	ATP11B	MGD	MGI:1923545
Bos taurus	ATP11B	VGNC	VGNC:54671
Others	ATP11B	NCBI