GNB2 - G protein subunit beta 2 Gene

Also Known as SSS4; HG2C1; SSS4; NEDHYDF

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2783

About GNB2

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:100,673,740-100,679,169 (from NCBI)

This gene has 13 transcripts (splice variants), 194 orthologues, 4 paralogues and is associated with 3 phenotypes. Ubiquitous expression in esophagus (RPKM 67.4), prostate (RPKM 65.4) and 25 other tissues.

Summary

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene contains a trinucleotide (CCG) repeat length polymorphism in its 5' UTR. [provided by RefSeq, Jul 2008]

GNB2 Products (1)

mRNA Protein Name
NM_005273.4 NP_005264.2 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables GTPase binding IPI
IPI: Inferred from physical interaction
19255495 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16498633 GOA
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
23209302 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in regulation of potassium ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
28219978 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
16498633 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
28219978 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GNB2 Protein Structure

WD40

WD40: WD domain, G-beta repeat (49 - 83)

WD40

WD40: WD domain, G-beta repeat (96 - 125)

WD40

WD40: WD domain, G-beta repeat (137 - 170)

WD40

WD40: WD domain, G-beta repeat (178 - 212)

WD40

WD40: WD domain, G-beta repeat (218 - 254)

WD40

WD40: WD domain, G-beta repeat (272 - 298)

WD40

WD40: WD domain, G-beta repeat (306 - 340)

  • 0
  • 100
  • 200
  • 300
  • 340 a.a.
Protein Preferred Names Protein Names

guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

  • G protein, beta-2 subunit

GNB2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
GNB2 P62879 UBE2Q1 Homo sapiens Q7Z7E8-2
Validated Y2H
32814053
Intra
GNB2 P62879 UBE2Q1 Homo sapiens Q7Z7E8-2
Y2H Array
32814053
Intra
GNB2 P62879 UBE2Q1 Homo sapiens Q7Z7E8-2
Y2H Pooling
32814053
Intra
GNB2 P62879 ATG10 Homo sapiens Q9H0Y0
Y2H Pooling
32814053
Intra
GNB2 P62879 ATG10 Homo sapiens Q9H0Y0
Validated Y2H
32814053
Intra
GNB2 P62879 ATG10 Homo sapiens Q9H0Y0
Y2H Array
32814053
Intra
GNB2 P62879 UBE2L6 Homo sapiens O14933
Y2H Array
32814053
Intra
GNB2 P62879 UBE2L6 Homo sapiens O14933
Validated Y2H
32814053
Intra
GNB2 P62879 UBE2L6 Homo sapiens O14933
Y2H Pooling
32814053
Intra
GNB2 P62879 UBE2Q2 Homo sapiens Q8WVN8
Y2H Pooling
32814053
Intra
GNB2 P62879 UBE2Q2 Homo sapiens Q8WVN8
Validated Y2H
32814053
Intra
GNB2 P62879 UBE2Q2 Homo sapiens Q8WVN8
Y2H Array
32814053
Intra
GNB2 P62879 UBE2U Homo sapiens Q5VVX9-2
Validated Y2H
32814053
Intra
GNB2 P62879 UBE2U Homo sapiens Q5VVX9-2
Y2H Array
32814053
Intra
GNB2 P62879 UBE2U Homo sapiens Q5VVX9-2
Y2H Pooling
32814053
Intra
GNB2 P62879 UBE2O Homo sapiens Q9C0C9
Y2H Array
32814053
Intra
GNB2 P62879 UBE2O Homo sapiens Q9C0C9
Validated Y2H
32814053
Intra
GNB2 P62879 UBE2O Homo sapiens Q9C0C9
Y2H Pooling
32814053
Intra
GNB2 P62879 UBE2J2 Homo sapiens Q8N2K1
Y2H Pooling
32814053
Intra
GNB2 P62879 UBE2J2 Homo sapiens Q8N2K1
Validated Y2H
32814053
Intra
GNB2 P62879 UBE2J2 Homo sapiens Q8N2K1
Y2H Array
32814053
Intra
GNB2 P62879 UBE2D2 Homo sapiens P62837
Y2H Array
32814053
Intra
GNB2 P62879 UBE2D2 Homo sapiens P62837
Y2H Pooling
32814053
Intra
GNB2 P62879 UBE2D2 Homo sapiens P62837
Validated Y2H
32814053
Intra
GNB2 P62879 UBE2D3 Homo sapiens P61077
Y2H Pooling
32814053
Intra
GNB2 P62879 UBE2D3 Homo sapiens P61077
Validated Y2H
32814053
Intra
GNB2 P62879 UBE2D3 Homo sapiens P61077
Y2H Array
32814053
Intra
GNB2 P62879 TARDBP Homo sapiens Q13148
Y2H Array
32814053
Intra
GNB2 P62879 TARDBP Homo sapiens Q13148
Y2H Pooling
32814053
Intra
GNB2 P62879 TARDBP Homo sapiens Q13148
Anti Tag CoIP
28514442
Intra
GNB2 P62879 TARDBP Homo sapiens Q13148
Validated Y2H
32814053
Intra
GNB2 P62879 RNF11 Homo sapiens Q9Y3C5
Y2H Pooling
32814053
Intra
GNB2 P62879 RNF11 Homo sapiens Q9Y3C5
Validated Y2H
32814053
Intra
GNB2 P62879 RNF11 Homo sapiens Q9Y3C5
Y2H Array
32814053
Intra
GNB2 P62879 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
GNB2 P62879 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
GNB2 P62879 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
GNB2 P62879 UBE2D1 Homo sapiens P51668
Validated Y2H
32814053
Intra
GNB2 P62879 UBE2D1 Homo sapiens P51668
Y2H Array
32814053
Intra
GNB2 P62879 UBE2D1 Homo sapiens P51668
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

GNB2 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P81868 GNB2 Antibody (YA1613) WB, IHC-P, IP Human, Mouse, Rat
HY-P81868A GNB2 Antibody (YA1613)(PBS only) WB, IHC-P, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Sick Sinus Syndrome 4

  • SSS4
Neurodevelopmental Disorder With Hypotonia And Dysmorphic Facies

  • NEDHYDF
Sturge-Weber Syndrome

  • SWS

  • Encephalotrigeminal Angiomatosis

  • Encephalofacial Angiomatosis

  • Sturge-Weber-Dimitri Syndrome

  • Sturge-Weber-Krabbe Syndrome

  • Fourth Phacomatosis

  • Leptomeningeal Angiomatosis

  • Meningeal Capillary Angiomatosis

  • Sturge-Weber-Krabbe Angiomatosis

  • Sturge-Weber Syndrome, Somatic, Mosaic

  • Sws Type I - Facial And Leptomeningeal Angiomas

  • Sws Type Ii - Facial Angioma Alone, No Cns Involvement

  • Sws Type Iii - Isolated Leptomeningeal Angiomas

  • Sturge Weber Syndrome

  • Angiomatosis Aculoorbital-Thalamic Syndrome

  • Encephalofacial Hemangiomatosis

  • Encephalofacial Hemangiomatosis Syndrome

  • Meningo-Oculo-Facial Angiomatosis

  • Meningofacial Angiomatosis-Cerebral Calcification Syndrome

  • Neuroretinoangiomatosis

  • Phakomatosis, Sturge-Weber

  • Weber-Sturge-Dimitri Syndrome
Sick Sinus Syndrome

  • Sinus Node Dysfunction

  • Sinus Node Disease

  • Sinus Node Infection

  • Snd

  • Sss

  • Snd - [Sinus Node Dysfunction]

  • Sinoatrial Node Dysfunction

  • Sss - [Sick Sinus Syndrome]

  • Sick Sinus

  • Sick Sinus Tachycardia
Night Blindness, Congenital Stationary, Type 1h

  • Congenital Stationary Night Blindness 1h

  • CSNB1H

  • Congenital Stationary Night Blindness Type 1h

  • Night Blindness, Congenital Stationary, 1h
Progressive Familial Heart Block, Type Ib

  • Progressive Familial Heart Block Type Ib

  • PFHB1B

  • Pfhbib

  • Progressive Familial Heart Block Type 1b

  • Heart Block Progressive Familial Type 1b

  • Progressive Familial Heart Block 1b

  • Cardiac Conduction Block

  • Right-Bundle Branch Block

  • Heart Block, Familial, Progressive, Type 1b

  • Heart Block

  • Right Bundle Branch Block
Weber Syndrome

  • Midbrain Stroke Syndromes
Night Blindness, Congenital Stationary, Autosomal Dominant 2

  • Congenital Stationary Night Blindness Autosomal Dominant 2

  • CSNBAD2

  • Hemeralopia

  • Night Blindness, Congenital Stationary, Rambusch Type

  • Rambusch Type Congenital Stationary Night Blindness

  • Congenital Stationary Night Blindness Rambusch Type

  • Hemeralopia Congenital Essential

  • Blindness, Night, Stationary, Congenital, Autosomal Dominant, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS05547 GNB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19336 Gnb2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25827 Gnb2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus GNB2 RGD RGD:69319
Mus musculus GNB2 MGD MGI:95784
Canis familiaris GNB2 VGNC VGNC:41313
Macaca mulatta GNB2 VGNC VGNC:81318
Felis catus GNB2 VGNC VGNC:62621
Bos taurus GNB2 VGNC VGNC:29459
Others GNB2 NCBI