UBE2Q2 - ubiquitin conjugating enzyme E2 Q2 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 92912

About UBE2Q2

Cytogenetic location: 15q24.2 Genomic coordinates (GRCh38): 15:75,843,447-75,901,078 (from NCBI)

This gene has 8 transcripts (splice variants), 266 orthologues and 12 paralogues. Ubiquitous expression in thyroid (RPKM 12.2), prostate (RPKM 10.7) and 25 other tissues.

Summary

Enables ubiquitin-protein transferase activity. Involved in protein K48-linked ubiquitination. Predicted to be located in cytosol. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

UBE2Q2 Products (3)

mRNA Protein Name
NM_001145335.1 NP_001138807.1 ubiquitin-conjugating enzyme E2 Q2 isoform 2
NM_001284382.2 NP_001271311.1 ubiquitin-conjugating enzyme E2 Q2 isoform 3
NM_173469.4 NP_775740.1 ubiquitin-conjugating enzyme E2 Q2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32814053 GOA
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
20061386 GOA
Biological Process GO Annotation Evidence References Source
involved in protein K48-linked ubiquitination IDA
IDA: Inferred from direct assay
20061386 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBE2Q2 Protein Structure

RWD

RWD: RWD domain (7 - 93)

UQ_con

UQ_con: Ubiquitin-conjugating enzyme (267 - 359)

  • 0
  • 100
  • 200
  • 300
  • 375 a.a.
Protein Preferred Names Protein Names

ubiquitin-conjugating enzyme E2 Q2

  • E2 ubiquitin-conjugating enzyme Q2

UBE2Q2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
UBE2Q2 Q8WVN8 HSPB1 Homo sapiens P04792
Y2H Pooling
32814053
Intra
UBE2Q2 Q8WVN8 HSPB1 Homo sapiens P04792
Validated Y2H
32814053
Intra
UBE2Q2 Q8WVN8 HSPB1 Homo sapiens P04792
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15359 UBE2Q2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus UBE2Q2 MGD MGI:2388672
Rattus norvegicus UBE2Q2 RGD RGD:1307680
Bos taurus UBE2Q2 VGNC VGNC:36593
Macaca mulatta UBE2Q2 VGNC VGNC:79188
Felis catus UBE2Q2 VGNC VGNC:66764
Canis familiaris UBE2Q2 VGNC VGNC:48062
Others UBE2Q2 NCBI