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  4. Monoclonal Antibodies Recombinant Antibodies
  5. GNB2 Antibody (YA1613)

GNB2 Antibody (YA1613) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GNB2.

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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

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  • Descripciòn

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Descripciòn

GNB2 Antibody (YA1613) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GNB2.
Host

Rabbit
Clonality

Recombinant, Monoclonal
Peso molecular
Predicted band size: 37 kDa;
Observed band size: 32 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human, Mouse, Rat
SwissProt ID
Gene ID
Immunogen

A synthetic peptide of human GNB2
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:1000
IHC-P
IHC-P: Immunohistochemistry-Paraffin
1:50-1:100
IP
IP: Immunoprecipitation
1:20
Sensitivity Endogenous Pureza Affinity Purified
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Envío

Shipping with blue ice.
Verification Image
WB

  • Western blot analysis was performed on extracts from Hela (lane 1, 15 μg), SH-SY5Y (lane 2, 15 μg), Jurkat (lane 3, 15 μg), C6 (lane 4, 15 μg), Mouse brain (lane 5, 15 μg), and Rat brain (lane 6, 15 μg) using GNB2 Rabbit mAb.Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST at 4°C overnight.The primary antibody (1:1000 dilution) and the loading control antibody (beta-Actin, HY-P83730, 1:20000 dilution) were incubated in 5% non-fat milk in TBST for 1 hour at 37°C.Goat Anti-Rabbit IgG-HRP Secondary Antibody (1:20000 dilution) was then applied for 40 minutes at 37°C.

Background
Function：Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction
Subcellular Localization：Cytoplasm, perinuclear region; Cell membrane
Expression：
Tissue_specificity:Expressed in all cardiac subcompartments and in the brain, with highest levels in the atrioventricular node and brain
Isoforms & Post-Translational Modification：P62879 has 2 isomers: P62879-1: 37331 Da (predicted); P62879-2: 25931 Da (predicted).
Subunit：G proteins are composed of 3 units, alpha, beta and gamma. In this context, interacts with GNAI2 and GNG2 (PubMed:28219978). Interacts with ARHGEF18 and RASD2. Interacts with ATXN10. Interacts with SCN8A (PubMed:26900580)
Database

Entrez Gene: 2783 Human ; 14693 Mouse ; 81667 Rat

SwissProt: P62879 Human ; P62880 Mouse ; P54313 Rat

OMIM: 619503 Human

Research Field

Signal Transduction
Synonyms
Gnb2; Gnb2l1; RACK1; Transducin beta chain 2
Documentación
SDS (251 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)
Referencias

GNB2 Antibody (YA1613) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Inquiry Information

Nombre del producto:
GNB2 Antibody (YA1613)
Cat. No.:
HY-P81868
Cantidad:
MCE Japan Authorized Agent:

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