CLEC12B - C-type lectin domain family 12 member B Gene

Also Known as UNQ5782

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 387837

About CLEC12B

Cytogenetic location: 12p13.2 Genomic coordinates (GRCh38): 12:10,006,209-10,018,800 (from NCBI)

This gene has 5 transcripts (splice variants), 351 orthologues and 23 paralogues. Biased expression in testis (RPKM 8.0), skin (RPKM 1.6) and 1 other tissue.

Summary

Enables protein Phosphatase binding activity and signaling receptor inhibitor activity. Involved in natural killer cell inhibitory signaling pathway; negative regulation of natural killer cell mediated cytotoxicity; and negative regulation of signaling receptor activity. Located in external side of plasma membrane. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

CLEC12B Products (5)

mRNA Protein Name
NM_001129998.3 NP_001123470.1 C-type lectin domain family 12 member B isoform 1
NM_001319241.1 NP_001306170.1 C-type lectin domain family 12 member B isoform 3
NM_001319242.1 NP_001306171.1 C-type lectin domain family 12 member B isoform 4
NM_001387138.1 NP_001374067.1 C-type lectin domain family 12 member B isoform 5
NM_205852.3 NP_995324.2 C-type lectin domain family 12 member B isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein phosphatase binding IDA
IDA: Inferred from direct assay
34310951 GOA
enables protein phosphatase binding IPI
IPI: Inferred from physical interaction
17562706 GOA
enables signaling receptor inhibitor activity IMP
IMP: Inferred from mutant phenotype
17562706 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in melanocyte proliferation IDA
IDA: Inferred from direct assay
34310951 GOA
involved in natural killer cell inhibitory signaling pathway IMP
IMP: Inferred from mutant phenotype
17562706 GOA
involved in negative regulation of natural killer cell mediated cytotoxicity IMP
IMP: Inferred from mutant phenotype
17562706 GOA
involved in negative regulation of receptor signaling pathway via STAT IDA
IDA: Inferred from direct assay
34310951 GOA
involved in negative regulation of signaling receptor activity IMP
IMP: Inferred from mutant phenotype
17562706 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in external side of plasma membrane IMP
IMP: Inferred from mutant phenotype
17562706 GOA
part of protein-containing complex IMP
IMP: Inferred from mutant phenotype
17562706 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLEC12B Protein Structure

Ly49

Ly49: Ly49-like protein, N-terminal region (38 - 157)

Lectin_C

Lectin_C: Lectin C-type domain (162 - 265)

  • 0
  • 100
  • 200
  • 276 a.a.
Protein Preferred Names Protein Names

C-type lectin domain family 12 member B

  • macrophage antigen h

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS02782 CLEC12B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CLEC12B MGD MGI:1918433
Macaca mulatta CLEC12B VGNC VGNC:71378
Felis catus CLEC12B VGNC VGNC:60942
Rattus norvegicus CLEC12B RGD RGD:1560487
Canis familiaris CLEC12B VGNC VGNC:39326
Bos taurus CLEC12B VGNC VGNC:27424
Others CLEC12B NCBI