Ifih1 - interferon induced with helicase C domain 1 Gene

Also Known as Hlcd; MDA5; RLR-2; Helicard; 9130009C22Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 71586

Summary

Predicted to enable several functions, including RNA binding activity; identical protein binding activity; and zinc ion binding activity. Involved in innate immune response and response to virus. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome. Orthologous to human IFIH1 (interferon induced with helicase C domain 1). [provided by Alliance of Genome Resources, Apr 2022]

Ifih1 Products (2)

mRNA Protein Name
NM_001164477.1 NP_001157949.1 interferon-induced helicase C domain-containing protein 1 isoform 2
NM_027835.3 NP_082111.2 interferon-induced helicase C domain-containing protein 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
21791617 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within antiviral innate immune response IMP
IMP: Inferred from mutant phenotype
28031478 MGI
involved in innate immune response IMP
IMP: Inferred from mutant phenotype
17942531 MGI
acts upstream of or within interferon-beta production IMP
IMP: Inferred from mutant phenotype
28031478 MGI
acts upstream of or within protein complex oligomerization IDA
IDA: Inferred from direct assay
28031478 MGI
involved in response to virus IMP
IMP: Inferred from mutant phenotype
17942531 MGI
acts upstream of or within type I interferon-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
28031478 MGI
Cellular Component GO Annotation Evidence Verweise Source
located in cytoplasm IDA
IDA: Inferred from direct assay
28031478 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interferon-induced helicase C domain-containing protein 1

  • RIG-I-like receptor 2

  • helicase with 2 CARD domains

  • interferon induced with helicase C domain protein 1

  • melanoma differentiation-associated protein 5

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS06559 IFIH1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18521 Ifih1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25003 Ifih1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ifih1 NCBI NCBI:64135