Lonp1 - lon peptidase 1, mitochondrial Gene

Also Known as LON; Prss15; 1200017E13Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 74142

Summary

Enables ATP hydrolysis activity; ATP-dependent peptidase activity; and DNA binding activity. Acts upstream of or within proteolysis. Located in mitochondrion. Is expressed in several structures, including adrenal medulla; alimentary system; genitourinary system; liver; and lung. Human ortholog(s) of this gene implicated in CODAS syndrome. Orthologous to human LONP1 (lon peptidase 1, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]

Lonp1 Products (1)

mRNA Protein Name
NM_028782.2 NP_083058.2 lon protease homolog, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables ATP hydrolysis activity IDA
IDA: Inferred from direct assay
12657466 MGI
enables ATP-dependent peptidase activity IDA
IDA: Inferred from direct assay
12657466 MGI
enables PH domain binding IPI
IPI: Inferred from physical interaction
9813005 MGI
enables insulin receptor substrate binding IPI
IPI: Inferred from physical interaction
9813005 MGI
NOT enables mitochondrial promoter sequence-specific DNA binding IDA
IDA: Inferred from direct assay
12657466 MGI
enables mitochondrial promoter sequence-specific DNA binding IDA
IDA: Inferred from direct assay
12657466 MGI
enables single-stranded DNA binding IDA
IDA: Inferred from direct assay
12657466 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within negative regulation of insulin receptor signaling pathway IDA
IDA: Inferred from direct assay
9813005 MGI
acts upstream of or within proteolysis IDA
IDA: Inferred from direct assay
12657466 MGI
acts upstream of or within regulation of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
9813005 MGI
Cellular Component GO Annotation Evidence Verweise Source
located in mitochondrion IDA
IDA: Inferred from direct assay
12657466 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lon protease homolog, mitochondrial

  • LONP

  • lon protease-like protein

  • mitochondrial ATP-dependent protease Lon

  • protease, serine, 15

  • serine protease 15

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-153034 LONP1-IN-2 99.43% Unkown
HY-158412 BT317 99.81% Unkown
HY-RS07734 LONP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24767 Lonp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18289 Lonp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lonp1 NCBI NCBI:9361