PPP1R3F - protein phosphatase 1 regulatory subunit 3F Gene

Also Known as R3F; HB2E; LL0XNC01-7P3.1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 89801

About PPP1R3F

This gene has 6 transcripts (splice variants), 112 orthologues and 6 paralogues. Broad expression in brain (RPKM 2.6), heart (RPKM 1.4) and 23 other tissues.

Summary

This gene encodes a protein that has been identified as one of several type-1 protein Phosphatase (PP1) regulatory subunits. One or two of these subunits, together with the well-conserved catalytic subunit, can form the PP1 holoenzyme, where the regulatory subunit functions to regulate substrate specificity and/or targeting to a particular cellular compartment. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

PPP1R3F Products (2)

mRNA	Protein	Name
NM_001184745.2	NP_001171674.1	protein phosphatase 1 regulatory subunit 3F isoform 2
NM_033215.5	NP_149992.3	protein phosphatase 1 regulatory subunit 3F isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables glycogen binding	IDA IDA: Inferred from direct assay	21668450	GOA
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	21668450	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
acts upstream of or within regulation of glycogen (starch) synthase activity	IDA IDA: Inferred from direct assay	21668450	GOA
acts upstream of or within regulation of glycogen biosynthetic process	IDA IDA: Inferred from direct assay	21668450	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in membrane	IDA IDA: Inferred from direct assay	21668450	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
protein phosphatase 1 regulatory subunit 3F	protein phosphatase 1, regulatory (inhibitor) subunit 3F

Related Diseases

Diseases	Alias
Joubert Syndrome 23	JBTS23 Joubert Syndrome, Type 23
Spinocerebellar Ataxia 29	Spinocerebellar Ataxia Type 29 SCA29 Cnpca Cerebellar Vermis Aplasia Aplasia Of Cerebellar Vermis Acv Cerebellar Ataxia, Congenital Nonprogressive, Autosomal Dominant Spinocerebellar Ataxia 29, Congenital Nonprogressive Congenital Nonprogressive Spinocerebellar Ataxia Autosomal Dominant Congenital Nonprogressive Cerebellar Ataxia Ataxia, Spinocerebellar, Type 29, Congenital Nonprogressive Familial Aplasia Of The Vermis
Parkinsonism With Spasticity, X-Linked	X-Linked Parkinsonism-Spasticity Syndrome XPDS X-Linked Parkinsonism With Spasticity
Stocco Dos Santos Type X-Linked Intellectual Disability	X-Linked Intellectual Disability, Stocco Dos Santos Type Stocco Dos Santos Syndrome Sdsx Stocco Dos Santos X-Linked Mental Retardation Syndrome
Spinocerebellar Ataxia 13	Spinocerebellar Ataxia Type 13 SCA13 Autosomal Dominant Cerebellar Ataxia With Intellectual Disability Cerebellar Ataxia, Autosomal Dominant With Intellectual Disability Spinocerebellar Ataxia-13 Ataxia, Spinocerebellar, Type 13
Spinocerebellar Ataxia 5	Spinocerebellar Ataxia Type 5 SCA5 Spinocerebellar Ataxia-5 Ataxia, Spinocerebellar, Type 5
Adenoiditis	Chronic Adenoiditis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS11001	PPP1R3F Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PPP1R3F	VGNC	VGNC:33247
Mus musculus	PPP1R3F	MGD	MGI:1859617
Canis familiaris	PPP1R3F	VGNC	VGNC:44901
Rattus norvegicus	PPP1R3F	RGD	RGD:1566398
Others	PPP1R3F	NCBI