Inbakicept
Based on 2 publication(s) in Google Scholar
Inbakicept is a dimeric human IL-15 receptor alpha (IL-15 Ra) sushi domain/human IgG1 Fc fusion protein and is an IL-15 superagonist complex. Inbakicept is able to form complex N-803 (Nogapendekin alfa inbakicept) with the IL-15 antibody Nogapendekin alfa in a 1:2 ratio. N-803 mimics the function of IL-15 and amplifies anti-CD20 mAb-mediated NK cell responses and antibody-dependent cellular cytotoxicity (ADCC). N-803 also increases degranulation and IFNγ production in cells.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: ≥99.0%
- CAS. Nr.: 2135939-52-3
- Molecular Weight:66.58 kDa
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Inbakicept
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Biologische Aktivität
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IL-15Rα |
Inbakicept (0.01-1 nM; 20 hr) enhances human NK cell cytotoxicity and increases cytotoxic effector molecule expression[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Daudi, Raji, CD19+ FL cells
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Concentration:0.01 nM, 0.1 nM, and 1 nM
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Incubation Time:20 hours
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Result:Increased the human NK cell cytotoxicity on Daudi, Raji, CD19+ FL cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:SCID mice with Daudi models[1]
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Dosage:0.02 mg/kg, 0.05 mg/kg, 0.1 mg/kg, and 0.2 mg/kg
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Administration:Intravenous injection; twice weekly, for 2 weeks
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Result:Enhanced rituximab-directed control of Raji lymphoma challenge.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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[IL15RA (interleukin 15 receptor subunit alpha, CD215, IL-15RA)]2-IGHG1 Fc (Fragment constant)
ELISA, FACS, Functional assay
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Immobilized Human IL-15 Protein can bind Inbakicept. The EC50 for this effect is 50.78 ng/mL.
Chemical Information
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CAS. Nr. 2135939-52-3
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Appearance Liquid
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Molecular Weight 66.58 kDa
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Color Colorless to light yellow
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SMILES
[Inbakicept]
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Versand
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
TSC22 domain family member 3 links natural killer cells to CD8+ T cell-mediated drug hypersensitivity. [Abstract]2025 Jun 21;10(1):196. PMID: 40544157 -
Cell Rep Med
Local delivery of IL-15 and anti-PD-L1 nanobody by in vitro-transcribed circILNb elicits superior antitumor immunity in cold tumors. [Abstract]2025 Oct 21;6(10):102413. PMID: 41075789
Reinheit & Dokumentation
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Data Sheet (261 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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