iNOs-IN-3
iNOs-IN-3 (Compound 2d) is an orally active nitric oxide synthase (iNOS) inhibitor (IC50=3.342 µM). iNOs-IN-3 shows anti-inflammatory activity and can be used in LPS-induced acute lung injury (ALI) research.
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- CAS. Nr.: 2241674-94-0
- Formel: C27H24N2O5S
- Molecular Weight:488.55
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
IC50: 3.342 µM (iNOS)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RAW264.7 | IC50 |
3.342 μM
Compound: 2d
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Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide synthase production measured after 24 hrs by ELISA
Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide synthase production measured after 24 hrs by ELISA
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[PMID: 33065432] |
iNOs-IN-3 (25 μM; 24 h) inhibits LPS-induced RAW 264.7 cells[1].
iNOs-IN-3 (12.5 μM; 24 h) can decrease the expression of iNOS[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW 264.7 microphages
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Concentration:25 μM
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Incubation Time:24 hours
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Result:Showed higher inhibitory activity (IC50=14.72 µM) in LPS-induced RAW 264.7 cells.
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Cell Line:RAW 264.7 microphages
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Concentration:12.5 μM
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Incubation Time:24 hours
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Result:Inhibited the LPS-induced mRNA expression of iNOS obviously.
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Cell Line:RAW 264.7 microphages
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Concentration:12.5 μM
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Incubation Time:24 hours
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Result:Inhibited the expression of TNF-α, IL-6, and IL-1β at 12.5 µM.
iNOs-IN-3 (oral administration; 3.125 mg/kg, 6.25 mg/kg, 12.5 mg/kg; once) protects against LPS-induced acute lung injury[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Xylene-induced mice[1]
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Dosage:12.5 mg/kg
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Administration:Oral administration; 12.5 mg/kg; once
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Result:Showed better activity than the positive control.
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Animal Model:LPS-induced acute lung injury (ALI) mice[1]
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Dosage:3.125 mg/kg, 6.25 mg/kg, 12.5 mg/kg
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Administration:Oral administration; 3.125 mg/kg, 6.25 mg/kg, 12.5 mg/kg; once
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Result:Attenuated the pathological lesions dose-dependently, such as decreased inflammatory infiltration and pulmonary congestion. Inhibited LPS-induced lung edema dose-dependently.
Chemical Information
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CAS. Nr. 2241674-94-0
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Molecular Weight 488.55
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Formel C27H24N2O5S
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SMILES
O=C1OC2=CC=CC(OS(=O)(C3=CC=CC4=C(N(C)C)C=CC=C43)=O)=C2N1CCC5=CC=CC=C5
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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