AKT3 Protein, Human (Active, sf9, GST)

AKT2, a crucial member of the AKT kinase family along with AKT1 and AKT3, orchestrates a myriad of cellular processes, including metabolism, proliferation, cell survival, growth, and angiogenesis. Operating through the phosphorylation of numerous downstream substrates, AKT2 influences over 100 reported targets, exhibiting remarkable functional diversity. It governs insulin-induced glucose uptake by facilitating SLC2A4/GLUT4 translocation and intricately regulates insulin signaling pathways. Additionally, AKT2 modulates glycogen storage, inhibits GSK3 kinase activity, and plays a pivotal role in the AKT-mTOR signaling pathway, influencing neurogenesis and cellular migration dynamics. AKT2's involvement in phosphorylating FOXO factors, CREB1, and multiple targets related to metabolism underscores its pivotal position in cellular homeostasis. Notably, AKT2 exhibits isoform-specific functions, with a significant role in regulating glucose uptake and participating in intricate processes such as skeletal muscle differentiation. The recent identification of specific substrates like PITX2 and ANKRD2 further delineates AKT2's nuanced and intricate cellular regulatory roles.