669 Results for "

native

" in MedChemExpress (MCE) Product Catalog:
Products (669)

669 Results for "native" in MCE Product Catalog:

54
Bovine Serum Albumin
Bovine Serum Albumin
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54 Publications Verification
Art. -Nr.: HY-D0842
CAS. Nr.: 9048-46-8
Synonyms: Albumin bovine serum; BSA
Bovine Serum Albumin (BSA) is a 583-residue protein consisting of three homologous all-α domains, organized in a heart-shaped structure. BSA is a globular protein that is used in numerous biochemical applications.
16
Octreotide acetate
Octreotide acetate
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16 Cited Publications
Art. -Nr.: HY-17365
CAS. Nr.: 79517-01-4
Synonyms: SMS 201-995 acetate
Target:  

Somatostatin Receptor

Forschungsgebiete:  

Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer

Octreotide acetate, a long-acting synthetic analog of native somatostatin, inhibits growth hormone, glucagon, and insulin more potently.
13
DAMGO
DAMGO
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13 Cited Publications
Art. -Nr.: HY-P0210
CAS. Nr.: 78123-71-4
Target:  

Opioid Receptor

Forschungsgebiete:  

Cancer

DAMGO is a μ-opioid receptor (μ-OPR ) selective agonist with a Kd of 3.46 nM for native μ-OPR .
13
DAMGO TFA
DAMGO TFA
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13 Cited Publications
Art. -Nr.: HY-P0210B
CAS. Nr.: 950492-85-0
Target:  

Opioid Receptor

Forschungsgebiete:  

Cancer

DAMGO TFA is a μ-opioid receptor (μ-OPR ) selective agonist with a Kd of 3.46 nM for native μ-OPR .
10
Olverembatinib
Olverembatinib
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10 Cited Publications
Art. -Nr.: HY-15666
CAS. Nr.: 1257628-77-5
Reinheit:  99.65%
Synonyms: GZD824; HQP1351
Target:  

Bcr-Abl

Forschungsgebiete:  

Cancer

Olverembatinib (GZD824) is a potent and orally active pan-Bcr-Abl inhibitor. Olverembatinib potently inhibits a broad spectrum of Bcr-Abl mutants. Olverembatinib strongly inhibits native Bcr-Abl and Bcr-Abl T315I with IC50s of 0.34 nM and 0.68 nM, respectively. Olverembatinib has antitumor activity . Olverembatinib is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
10
Olverembatinib dimesylate
Olverembatinib dimesylate
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10 Cited Publications
Art. -Nr.: HY-15666A
CAS. Nr.: 1421783-64-3
Reinheit:  99.81%
Synonyms: GZD824 dimesylate; HQP1351 dimesylate
Target:  

Bcr-Abl

Forschungsgebiete:  

Cancer

Olverembatinib (GZD824) dimesylate is a potent and orally active pan-Bcr-Abl inhibitor. Olverembatinib dimesylate potently inhibits a broad spectrum of Bcr-Abl mutants. Olverembatinib dimesylate strongly inhibits native Bcr-Abl and Bcr-Abl T315I with IC50s of 0.34 nM and 0.68 nM, respectively. Olverembatinib dimesylate has antitumor activity . Olverembatinib (dimesylate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
10
PPADS tetrasodium
PPADS tetrasodium
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10 Cited Publications
Art. -Nr.: HY-101044
CAS. Nr.: 192575-19-2
Reinheit:  ≥95.0%
Target:  

P2X Receptor Na+/Ca2+ Exchanger

Forschungsgebiete:  

Neurological Disease

PPADS tetrasodiuma is a non-selective P2X receptor antagonist. PPADS tetrasodiuma blocks recombinant P2X1, -2, -3, -5 with IC50s ranging from 1 to 2.6 μM. PPADS tetrasodiuma blocks native P2Y2-like (IC50~0.9 mM) and recombinant P2Y4 (IC50~15 mM) receptors. PPADS tetrasodiuma is an inhibitor of the reverse mode of the Na/Ca 2+ exchanger in guinea pig airway smooth muscle .
9
Agomelatine
Agomelatine
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9 Cited Publications
Art. -Nr.: HY-17038
CAS. Nr.: 138112-76-2
Synonyms: S-20098
Category:  

Alkaloids Neurological Disease Other Alkaloids Endogenous metabolite Disease Research Fields

Target:  

Melatonin Receptor 5-HT Receptor Endogenous Metabolite

Agomelatine (S-20098) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively . Agomelatine is a selective 5-HT2C receptor antagonist with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively .
9
Agomelatine hydrochloride
Agomelatine hydrochloride
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9 Cited Publications
Art. -Nr.: HY-17038A
CAS. Nr.: 1176316-99-6
Synonyms: S-20098 hydrochloride
Category:  

Alkaloids Neurological Disease Other Alkaloids Endogenous metabolite Disease Research Fields

Target:  

Melatonin Receptor 5-HT Receptor Endogenous Metabolite

Agomelatine hydrochloride (S-20098 hydrochloride) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively . Agomelatine hydrochloride is a selective 5-HT2C receptor antagonist with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively .
9
Agomelatine (L(+)-Tartaric acid)
Agomelatine (L(+)-Tartaric acid)
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9 Cited Publications
Art. -Nr.: HY-17038B
CAS. Nr.: 824393-18-2
Synonyms: S-20098 L(+)-Tartaric acid
Category:  

Alkaloids Neurological Disease Other Alkaloids Endogenous metabolite Disease Research Fields

Target:  

Melatonin Receptor 5-HT Receptor Endogenous Metabolite

Agomelatine L(+)-Tartaric acid (S-20098 L(+)-Tartaric acid) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively . Agomelatine L(+)-Tartaric acid is a selective 5-HT2C receptor antagonist with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively .
8
Fibronectin
Fibronectin
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8 Cited Publications
Art. -Nr.: HY-P3160
CAS. Nr.: 86088-83-7
Category:  

Cardiovascular Disease Natural Products Endogenous metabolite Disease Research Fields

Target:  

Integrin

Fibronectin, a glycoprotein present in blood as well as in cells, is a biomarker of tissue injury. Fibronectin binds to membrane-spanning receptor proteins called integrins. Fibronectin also binds to other extracellular matrix proteins such as collagen, fibrin, and heparan sulfate proteoglycans .
This product is a human Fibronectin obtained by recombinant expression in a rice expression system.
7
AkaLumine hydrochloride
AkaLumine hydrochloride
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7 Cited Publications
Art. -Nr.: HY-112641A
CAS. Nr.: 2558205-28-8
Reinheit:  99.92%
AkaLumine hydrochloride is a D-luciferin (HY-12591A) analogue with a Km of 2.06 μM for recombinant firefly luciferase (Fluc) protein. AkaLumine hydrochloride emits near-infrared (NIR) light (λmax=677 nm) in reactions with native Fluc. AkaLumine hydrochloride has high tissue-penetration and increases detection sensitivity from deep-tissue targets .
7
eCF506
eCF506
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7 Cited Publications
Art. -Nr.: HY-112096
CAS. Nr.: 1914078-41-3
Reinheit:  99.17%
Synonyms: NXP900
Target:  

Src

Forschungsgebiete:  

Cancer

eCF506 (NXP900) is a highly potent and orally active YES1/SRC kinase inhibitor with an IC50 of 0.47 nM. eCF506 locks its target into its native “closed” conformation, thereby inhibiting both kinase activity and complex formation with protein partners. eCF506 can be used for the study of esophageal squamous cancer and breast cancer .
5
(-)-Epigallocatechin
(-)-Epigallocatechin
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5 Cited Publications
Art. -Nr.: HY-N0225
CAS. Nr.: 970-74-1
Synonyms: Epigallocatechin; L-Epigallocatechin
Category:  

Flavonoids Microorganisms Flavanols Phenols Polyphenols Plants Camellia sinensis (L.) O. Ktze. Disease Research Fields Cancer Theaceae

Target:  

MMP Autophagy

(-)-Epigallocatechin (Epigallocatechin) is the most abundant flavonoid in green tea, can bind to unfolded native polypeptides and prevent conversion to amyloid fibrils.
5
(-)-Epigallocatechin (Standard)
(-)-Epigallocatechin (Standard)
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5 Cited Publications
Art. -Nr.: HY-N0225R
CAS. Nr.: 970-74-1
Synonyms: Epigallocatechin(Standard); L-Epigallocatechin (Standard)
Category:  

Flavonoids Phenols Plants Camellia sinensis (L.) O. Ktze. Disease Research Fields Cancer Theaceae

Target:  

Reference Standards MMP Autophagy

(-)-Epigallocatechin (Standard) is the analytical standard of (-)-Epigallocatechin. This product is intended for research and analytical applications. (-)-Epigallocatechin (Epigallocatechin) is the most abundant flavonoid in green tea, can bind to unfolded native polypeptides and prevent conversion to amyloid fibrils.
5
Concanavalin A
Concanavalin A
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5 Cited Publications
Art. -Nr.: HY-P2149
CAS. Nr.: 11028-71-0
Concanavalin A can be coupled to agarose to form Concanavalin A (agarose) (HY-P2149A). Concanavalin A (ConA) is a selective, competitive binding agent that targets specific carbohydrate structures containing glucose and mannose; it acts as a mitogen and exhibits varying degrees of cytotoxicity, hepatotoxicity, and teratogenicity. Concanavalin A is also utilized for in vivo blood glucose monitoring in the context of diabetes .
5
Fetuin, Fetal Bovine Serum
Fetuin, Fetal Bovine Serum
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5 Cited Publications
Art. -Nr.: HY-P2352
CAS. Nr.: 9014-81-7
Category:  

Natural Products Animals Metabolic Disease Disease Research Fields

Target:  

Biochemical Assay Reagents

Fetuin, Fetal Bovine Serum is a liver-secreted 64 kDa plasma glycoprotein isolated from fetal bovine serum. Fetuin, Fetal Bovine Serum inhibits trypsin activity and promote cellular attachment, growth, and differentiation .
5
Streptavidin
Streptavidin
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5 Cited Publications
Art. -Nr.: HY-P3152
CAS. Nr.: 9013-20-1
Streptavidin is a ~60 kDa homotetramer. Streptavidin binds four molecules of biotin with the highest affinity. The binding affinity of biotin to streptavidin is one of the highest reported for a non-covalent interaction to date, with a KD ~0.01 pM . Streptavidin has an immunosuppressive role .
This product is a Streptavidin protein recombinantly expressed in an E. coli expression system.
4
SJB2-043
SJB2-043
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4 Cited Publications
Art. -Nr.: HY-15757
CAS. Nr.: 63388-44-3
Reinheit:  98.06%
Target:  

Deubiquitinase

Forschungsgebiete:  

Cancer

SJB2-043 is an inhibitor of the native USP1/UAF1 complex with IC50 of 544 nM.
4
Timapiprant
Timapiprant
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4 Cited Publications
Art. -Nr.: HY-15342
CAS. Nr.: 851723-84-7
Reinheit:  99.48%
Synonyms: OC000459
Target:  

Prostaglandin Receptor

Forschungsgebiete:  

Inflammation/Immunology Endocrinology

Timapiprant (OC000459) is a potent, selective, and orally active D prostanoid receptor 2 (DP2, also known as CRTH2) antagonist. Timapiprant (OC000459) potently displaces [ 3H] PGD2 from human recombinant DP2 (Ki=13 nM), rat recombinant DP2 (Ki=3 nM), and human native DP2 (Ki=4 nM). Timapiprant (OC000459) inhibits mast cell activation of Th2 lymphocytes and eosinophils .
Assay Types