TfR-T12 TFA
Based on 1 Customer Validation
TfR-T12 TFA is a BBB-penetrated transferrin receptor (TfR) binding peptide, displaying a binding affinity in the nM range.
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- Reinheit: 99.10%
- Formel: C73H100F3N19O17S
- Molecular Weight:1604.75
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Speicherung:
Sealed storage, away from moisture and light.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
TfR-T12 binds to the TfR and is subsequently internalized into TfR-expressing cells[1].
TfR-T12 is a synthetic peptide obtained by phage display, and is able to bind a different site on TfRs compared with transferrin. TfR-T12 can be chemically conjugated with a pegylated lipid derivative, 3-(N-succinimidyloxyglutaryl)aminopropyl- polyethyleneglycol(2000)- carbamyl distearoyl phosphatidylethanolamine (NHS-PEG2000-DSPE), and used as a functional material to construct the multifunctional lipid vesicles[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Molecular Weight 1604.75
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Formel C73H100F3N19O17S
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Color White to off-white
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Sequence
Thr-His-Arg-Pro-Pro-Met-Trp-Ser-Pro-Val-Trp-Pro
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Sequence Shortening
THRPPMWSPVWP
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Sealed storage, away from moisture and light
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Lösungsmittel & Löslichkeit
H2O : 100 mg/mL (62.32 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (280 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Carmen Wängler, et al. In Vitro and Initial in Vivo Evaluation of (68)Ga-labeled Transferrin Receptor (TfR) Binding Peptides as Potential Carriers for Enhanced Drug Transport Into TfR Expressing Cells. Mol Imaging Biol. 2011 Apr;13(2):332-41. [Content Brief]
[2]. Li-Min Mu, et al. Lipid Vesicles Containing Transferrin Receptor Binding Peptide TfR-T 12 and Octa-Arginine Conjugate stearyl-R 8 Efficiently Treat Brain Glioma Along With Glioma Stem Cells. Sci Rep. 2017 Jun 14;7(1):3487. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.6232 mL | 3.1158 mL | 6.2315 mL | 15.5788 mL |
| 5 mM | 0.1246 mL | 0.6232 mL | 1.2463 mL | 3.1158 mL | |
| 10 mM | 0.0623 mL | 0.3116 mL | 0.6232 mL | 1.5579 mL | |
| 15 mM | 0.0415 mL | 0.2077 mL | 0.4154 mL | 1.0386 mL | |
| 20 mM | 0.0312 mL | 0.1558 mL | 0.3116 mL | 0.7789 mL | |
| 25 mM | 0.0249 mL | 0.1246 mL | 0.2493 mL | 0.6232 mL | |
| 30 mM | 0.0208 mL | 0.1039 mL | 0.2077 mL | 0.5193 mL | |
| 40 mM | 0.0156 mL | 0.0779 mL | 0.1558 mL | 0.3895 mL | |
| 50 mM | 0.0125 mL | 0.0623 mL | 0.1246 mL | 0.3116 mL | |
| 60 mM | 0.0104 mL | 0.0519 mL | 0.1039 mL | 0.2596 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
TfR-T12 TFA Related Classifications
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