country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-153501

Copy Link Print Information

TrkA-IN-5

TrkA-IN-5 is a TrkA inhibitor with an IC₅₀ value of 1.678 nM against TrkA. TrkA-IN-5 can be used in cancer research.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 1377503-70-2
Formel: C₂₅H₁₈F₃N₅O₂S
Molecular Weight:509.51

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

TrkA-IN-5 Chemical Structure

CAS. Nr.: 1377503-70-2

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

TrkA-IN-5 is a TrkA inhibitor with an IC₅₀ value of 1.678 nM against TrkA. TrkA-IN-5 can be used in cancer research^[1].

IC₅₀ & Target^[1]

TrkA

1.678 nM (IC₅₀)

Alle Trk Receptor Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	GI	40 % Compound: 6t	Cytotoxicity against human MCF7 cells assessed as growth inhibition at 0.1 to 50 uM after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as growth inhibition at 0.1 to 50 uM after 48 hrs by MTT assay	[PMID: 22575050]
MCF7	IC₅₀	4.2 μM Compound: 6t	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 22575050]

In Vitro

TrkA-IN-5 (Compound 20) potently inhibits human TrkA (PDB ID: 4aoj) with an IC₅₀ value of 1.678 nM. It forms multiple stable hydrogen bonds and hydrophobic interactions with the active site of this protein, and its activity can be accurately predicted by CoMFA and CoMSIA 3D-QSAR models^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 1377503-70-2
Molecular Weight 509.51
Formel C₂₅H₁₈F₃N₅O₂S
SMILES

O=S(=O)(NC1=CC(N)=CC(=C1)C2=CN=C3NC=C(C=4C=CN=CC4)C3=C2)C=5C=CC=C(C5)C(F)(F)F
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Adnane Aouidate, et al. Molecular Docking and 3D-QSAR Studies on 7-azaindole Derivatives as
Inhibitors of Trk A: A Strategic Design in Novel Anticancer Agents. Letters in Drug Design & Discovery, 2018, 15, 1211-1223.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

Angebot einholen Auf Lager

Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

TrkA-IN-5

Alle Trk Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

TrkA-IN-5 Related Classifications

HY-153501 Related Classifications