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Cat. No.: HY-N1817

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Demethoxypiplartine

Demethoxypiplartine is an amide alkaloids which can be isolated from Piper flaviflorum and Piper sarmentosum. Demethoxypiplartine has antifungal activity against Cryptococcus neoformans with the IC₅₀ of 18.1 μg/mL.

For research use only. We do not sell to patients.

CAS No.: 130263-10-4
Formula: C₁₆H₁₇NO₄
Molecular Weight:287.31

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Demethoxypiplartine Chemical Structure

CAS No.: 130263-10-4

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Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
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Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	IC₅₀	3.7 μM Compound: 12	Antiproliferative activity in human MCF7 cells assessed as cell viability after 48 hrs by alamarBlue assay Antiproliferative activity in human MCF7 cells assessed as cell viability after 48 hrs by alamarBlue assay	[PMID: 27689728]
WI-38	EC₅₀	22.9 μM Compound: 10	Senolytic activity against non-senescent human WI38 cells assessed as reduction in cell viability by propidium iodide staining based flow cytometry Senolytic activity against non-senescent human WI38 cells assessed as reduction in cell viability by propidium iodide staining based flow cytometry	[PMID: 29925484]
WI-38	EC₅₀	8.3 μM Compound: 10	Senolytic activity against ionizing radiation induced human WI38 senescent cells assessed as reduction in cell viability by propidium iodide staining based flow cytometry Senolytic activity against ionizing radiation induced human WI38 senescent cells assessed as reduction in cell viability by propidium iodide staining based flow cytometry	[PMID: 29925484]

Chemical Information

CAS No. 130263-10-4
Molecular Weight 287.31
Formula C₁₆H₁₇NO₄
SMILES

O=C1C=CCCN1C(/C=C/C2=CC=C(OC)C(OC)=C2)=O
Structure Classification
- Alkaloids
- Pyridine Alkaloids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Shi YN, et al. Antifungal Amide Alkaloids from the Aerial Parts of Piper flaviflorum and Piper sarmentosum. Planta Med. 2017 Jan;83(1-02):143-150. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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Chemical Information
Purity & Documentation
References

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